Mechanisms underlying the antidepressant response of acupuncture via PKA/CREB signaling pathway

H Jiang, X Zhang, Y Wang, H Zhang, J Li… - Neural …, 2017 - Wiley Online Library
Protein kinase A (PKA)/cAMP response element‐binding (CREB) protein signaling pathway,
contributing to impaired neurogenesis parallel to depressive‐like behaviors, has been …

Acupuncture alleviates CUMS‐induced depression‐like behaviors by restoring prefrontal cortex neuroplasticity

P Li, W Huang, Y Chen, MS Aslam, W Cheng… - Neural …, 2023 - Wiley Online Library
Purpose. To explore the therapeutic efficiency of acupuncture and the related molecular
mechanism of neural plasticity in depression. Methods. Chronic unpredictable mild stress …

Mechanisms Underlying the Antidepressant Effect of Acupuncture via the CaMK Signaling Pathway

L Bai, D Zhang, TT Cui, JF Li, YY Gao… - Frontiers in Behavioral …, 2020 - frontiersin.org
The CaMK pathway has been proven to play an important role in regulating cognitive
function and emotional response. Acupuncture through the CaMK pathway improves …

Antidepressant-like effects of acupuncture involved the ERK signaling pathway in rats

X Zhang, Y Song, T Bao, M Yu, M Xu, Y Guo… - … and Alternative Medicine, 2016 - Springer
Background The extracellular signal-regulated kinase (ERK) signaling pathway is
considered to be associated with the pathogenesis and treatment of depression …

The role of MAPK and dopaminergic synapse signaling pathways in antidepressant effect of electroacupuncture pretreatment in chronic restraint stress rats

X Yang, Z Guo, J Lu, B Zhao, Y Fei, J Li… - Evidence‐Based …, 2017 - Wiley Online Library
Acupuncture has demonstrated the function in ameliorating depressive‐like behaviors via
modulating PKA/CREB signaling pathway. To further confirm the antidepressant mechanism …

Acupuncture activates ERK‐CREB pathway in rats exposed to chronic unpredictable mild stress

J Lu, J Liang, JR Wang, L Hu, Y Tu… - Evidence‐Based …, 2013 - Wiley Online Library
Extracellular signal‐regulated kinase (ERK)‐cAMP response element binding protein
(CREB) signal pathway has been implicated in the pathogenesis of depression. There is …

Effects of acupuncture on chronic stress-induced depression-like behavior and its central neural mechanism

MJ Lee, JS Ryu, SK Won, U Namgung, J Jung… - Frontiers in …, 2019 - frontiersin.org
Depression is a serious psychiatric disorder with an enormous socioeconomic burden, and it
is commonly comorbid with pain, chronic fatigue, or other inflammatory diseases. Recent …

The rapid antidepressant effect of acupuncture on two animal models of depression by inhibiting M1-Ach receptors regulates synaptic plasticity in the prefrontal cortex

B Ning, Z Wang, J He, Q Wu, Q Deng, Q Yang, J Gao… - Brain Research, 2024 - Elsevier
Background It is unclear whether acupuncture has a rapid antidepressant effect and what is
the main mechanism. Methods In this study, forced swimming stress test (FST) in mice were …

[PDF][PDF] Acupuncture therapies and neuroplasticity

CZ Liu, J Kong, KL Wang - Neural plasticity, 2017 - vbn.aau.dk
Neuroplasticity, including dendritic remodeling, synapse turnover, long-term potentiation
(LTP), and neurogenesis, is a feature of the brain's response to the environment. This …

Acupuncture relieves stress-induced depressive behavior by reducing oxidative stress and neuroapoptosis in rats

WJ Cheng, P Li, WY Huang, Y Huang… - Frontiers in Behavioral …, 2022 - frontiersin.org
Oxidative stress is closely related to the occurrence of depression. Acupuncture has been
proved to be an effective method for treating depression. In order to explore the mechanism …