Introduction To enhance the probability of pharmacodynamic target attainment, piperacillin–
tazobactam can be administered as either a continuous or extended-infusion dosage …

Objective: To perform a qualitative systematic review of the evidence comparing traditional
strategies against prolonged intermittent or continuous infusion strategies for piperacillin …

The aim was to assess the appropriateness of recommended regimens for empirical MIC
coverage in critically ill patients with open-abdomen and negative-pressure therapy …

We would like to thank for the opportunity to respond to the points raised in the commentary
by Mohammad H. Alshaer and Charles A. Peloquin and we thank the colleagues for the …

Objective The study was to establish a population pharmacokinetic (PPK) model of
piperacillin (PIP) and tazobactam (TAZ) that explain pharmacokinetic variability and to …

Abstract Background and Objective Tigecycline, a broad-spectrum glycylcycline antibiotic, is
approved for use at a fixed dose irrespective of body weight. However, its pharmacokinetics …

Background: Sustained low-efficiency dialysis (SLED), is increasingly being used in
intensive care units (ICUs) but studies informing drug dosing for such patients is lacking …

Objectives: We investigated the population pharmacokinetics and pharmacodynamics of
piperacillin and tazobactam in hospitalized patients. Patients and methods: A multicentre …

The objectives of this study were (i) to compare the plasma concentration–time profiles for
first-dose and steady-state piperacillin administered by intermittent or continuous dosing to …

The percentage of the time that the free drug concentration remains above a concentration
threshold (% fT> concentration threshold) has frequently been identified to be the optimal …