Synthesis and structure-activity relationship studies of α-naphthoflavone derivatives as CYP1B1 inhibitors
Abstract Cytochrome P450 1B1 (CYP1B1) has been recognized as an important target for
cancer prevention and drug resistance reversal. In order to obtain potent and selective …
cancer prevention and drug resistance reversal. In order to obtain potent and selective …
Discovery of heterocycle-containing α-naphthoflavone derivatives as water-soluble, highly potent and selective CYP1B1 inhibitors
Abstract Cytochrome P450 1B1 (CYP1B1) has been well validated as an attractive target for
cancer prevention and drug resistance reversal. In continuation of our interest in this area …
cancer prevention and drug resistance reversal. In continuation of our interest in this area …
Design and synthesis of selective CYP1B1 inhibitor via dearomatization of α-naphthoflavone
M Kubo, K Yamamoto, T Itoh - Bioorganic & Medicinal Chemistry, 2019 - Elsevier
Abstract Selective cytochrome P450 (CYP) 1B1 inhibition has potential as an anticancer
strategy that is unrepresented in the current clinical arena. For development of a selective …
strategy that is unrepresented in the current clinical arena. For development of a selective …
Design and synthesis of new α-naphthoflavones as cytochrome P450 (CYP) 1B1 inhibitors to overcome docetaxel-resistance associated with CYP1B1 overexpression
J Cui, Q Meng, X Zhang, Q Cui… - Journal of medicinal …, 2015 - ACS Publications
CYP1B1 is recognized as a new target in cancer prevention and therapy. Taking α-
naphthoflavone as a lead, a series of 6, 7, 10-trimethoxy-α-naphthoflavones (4a–o) were …
naphthoflavone as a lead, a series of 6, 7, 10-trimethoxy-α-naphthoflavones (4a–o) were …
Development of 2-arylbenzo [h] quinolone analogs as selective CYP1B1 inhibitors
The CYP1B1 enzyme is regarded as a potential target for cancer prevention and therapy.
Based on the structure of α-naphthoflavone (ANF), diverse 2-arylbenzo [h] quinolone …
Based on the structure of α-naphthoflavone (ANF), diverse 2-arylbenzo [h] quinolone …
Perspective of structural flexibility on selective inhibition towards CYP1B1 over CYP1A1 by α-naphthoflavone analogs
Y Wang, B Hu, Y Zhang, D Wang, Z Luo… - Physical Chemistry …, 2021 - pubs.rsc.org
Research on action selectivity between CYP1A1 and CYP1B1 is particularly valuable for
cancer chemoprevention and chemotherapy. However, they share a very close similarity in …
cancer chemoprevention and chemotherapy. However, they share a very close similarity in …
A new class of CYP1B1 inhibitors derived from bentranil
L Yi, X Huang, M Yang, J Cai, J Jia, Z Peng… - Bioorganic & Medicinal …, 2023 - Elsevier
Abstract Cytochrome P450 1B1 (CYP1B1) is highly expressed in a variety of tumors and
implicated to drug resistance. More and more researches have suggested that CYP1B1 is a …
implicated to drug resistance. More and more researches have suggested that CYP1B1 is a …
Flavonoids and naphthoflavonoids: wider roles in the modulation of cytochrome P450 family 1 enzymes
The human cytochrome P450 family 1 enzymes consist of three members, CYP1A1,
CYP1A2 and CYP1B1, which are predominantly involved in the phase I metabolism of …
CYP1A2 and CYP1B1, which are predominantly involved in the phase I metabolism of …
In silico guided designing of optimized benzochalcones derivatives as potent CYP1B1 inhibitors: An integrated in vitro and ONIOM study
Abstract Cytochrome P4501B1 (CYP1B1) is reported to be overexpressed in various
malignancies including ovarian, lung, lymph, and breast cancers. The overexpression of this …
malignancies including ovarian, lung, lymph, and breast cancers. The overexpression of this …
Discovery of 4'-trifluoromethylchalcones as novel, potent and selective hCYP1B1 inhibitors without concomitant AhR activation
Y Wu, JH Shi, GH Zhu, Y Xiong, JH Gong… - European Journal of …, 2023 - Elsevier
Abstract Human cytochrome P450 1B1 (hCYP1B1), an extrahepatic cytochrome P450
enzyme over-expressed in various tumors, has been validated as a promising target for …
enzyme over-expressed in various tumors, has been validated as a promising target for …