Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma
M Yamagishi, M Kubokawa, Y Kuze, A Suzuki… - Nature …, 2021 - nature.com
Subclonal genetic heterogeneity and their diverse gene expression impose serious
problems in understanding the behavior of cancers and contemplating therapeutic …
problems in understanding the behavior of cancers and contemplating therapeutic …
Targeted deep sequencing reveals clonal and subclonal mutational signatures in Adult T-cell leukemia/lymphoma and defines an unfavorable indolent subtype
Adult T-cell leukemia/lymphoma (ATL) carries a poor prognosis even in indolent subtypes.
We performed targeted deep sequencing combined with mapping of HTLV-1 proviral …
We performed targeted deep sequencing combined with mapping of HTLV-1 proviral …
Whole-genome landscape of adult T-cell leukemia/lymphoma
Adult T-cell leukemia/lymphoma (ATL) is an aggressive neoplasm immunophenotypically
resembling regulatory T cells, associated with human T-cell leukemia virus type-1. Here, we …
resembling regulatory T cells, associated with human T-cell leukemia virus type-1. Here, we …
Single-cell analysis of the multicellular ecosystem in viral carcinogenesis by HTLV-1
Premalignant clonal expansion of human T-cell leukemia virus type-1 (HTLV-1)–infected
cells occurs before viral carcinogenesis. Here we characterize premalignant cells and the …
cells occurs before viral carcinogenesis. Here we characterize premalignant cells and the …
RNA sequencing identifies clonal structure of T-cell repertoires in patients with adult T-cell leukemia/lymphoma
The diversity of T-cell receptor (TCR) repertoires, as generated by somatic DNA
rearrangements, is central to immune system function. High-throughput sequencing …
rearrangements, is central to immune system function. High-throughput sequencing …
Integrated molecular analysis of adult T cell leukemia/lymphoma
K Kataoka, Y Nagata, A Kitanaka, Y Shiraishi… - Nature …, 2015 - nature.com
Adult T cell leukemia/lymphoma (ATL) is a peripheral T cell neoplasm of largely unknown
genetic basis, associated with human T cell leukemia virus type-1 (HTLV-1) infection. Here …
genetic basis, associated with human T cell leukemia virus type-1 (HTLV-1) infection. Here …
Evolution of retrovirus-infected premalignant T-cell clones prior to adult T-cell leukemia/lymphoma diagnosis
Adult T-cell leukemia/lymphoma (ATL) is an aggressive hematological malignancy caused
by human T-cell leukemia virus type-1 (HTLV-1). ATL is preceded by decades of chronic …
by human T-cell leukemia virus type-1 (HTLV-1). ATL is preceded by decades of chronic …
The evolution of relapse of adult T cell acute lymphoblastic leukemia
Background Adult T cell acute lymphoblastic leukemia (T-ALL) is a rare disease that affects
less than 10 individuals in one million. It has been less studied than its cognate pediatric …
less than 10 individuals in one million. It has been less studied than its cognate pediatric …
Clonal evolution of adult T-cell leukemia/lymphoma takes place in the lymph nodes
A Umino, M Nakagawa, A Utsunomiya… - Blood, The Journal …, 2011 - ashpublications.org
Adult T-cell leukemia/lymphoma (ATLL) is the neoplasm caused by human T-cell leukemia
virus type 1 (HTLV-1). We performed oligo-array comparative genomic hybridization (CGH) …
virus type 1 (HTLV-1). We performed oligo-array comparative genomic hybridization (CGH) …
Adult T-cell leukemia: molecular basis for clonal expansion and transformation of HTLV-1–infected T cells
T Watanabe - Blood, The Journal of the American Society of …, 2017 - ashpublications.org
Adult T-cell leukemia (ATL) is an aggressive T-cell malignancy caused by human T-cell
leukemia virus type 1 (HTLV-1) that develops through a multistep carcinogenesis process …
leukemia virus type 1 (HTLV-1) that develops through a multistep carcinogenesis process …