[HTML][HTML] Drawing a line between histone demethylase KDM5A and KDM5B: their roles in development and tumorigenesis
J Yoo, GW Kim, YH Jeon, JY Kim, SW Lee… - … & Molecular Medicine, 2022 - nature.com
Distinct epigenetic modifiers ensure coordinated control over genes that govern a myriad of
cellular processes. Growing evidence shows that dynamic regulation of histone methylation …
cellular processes. Growing evidence shows that dynamic regulation of histone methylation …
[HTML][HTML] The diverse roles of histone demethylase KDM4B in normal and cancer development and progression
Z Wang, H Cai, E Zhao, H Cui - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Histone methylation status is an important process associated with cell growth, survival,
differentiation and gene expression in human diseases. As a member of the KDM4 family …
differentiation and gene expression in human diseases. As a member of the KDM4 family …
Advances in histone demethylase KDM4 as cancer therapeutic targets
DH Lee, GW Kim, YH Jeon, J Yoo, SW Lee… - The FASEB …, 2020 - Wiley Online Library
Abstract The KDM4 subfamily H3K9 histone demethylases are epigenetic regulators that
control chromatin structure and gene expression by demethylating histone H3K9, H3K36 …
control chromatin structure and gene expression by demethylating histone H3K9, H3K36 …
[HTML][HTML] Histone lysine demethylase (KDM) subfamily 4: structures, functions and therapeutic potential
RM Labbé, A Holowatyj, ZQ Yang - American journal of …, 2014 - ncbi.nlm.nih.gov
KDM4 histone demethylases catalyze the removal of methyl marks from histone lysine
residues to epigenetically regulate chromatin structure and gene expression. KDM4 …
residues to epigenetically regulate chromatin structure and gene expression. KDM4 …
[HTML][HTML] Histone demethylase lysine demethylase 5B in development and cancer
M Han, W Xu, P Cheng, H Jin, X Wang - Oncotarget, 2017 - ncbi.nlm.nih.gov
Histone methylation is one of the most important chromatin posttranslational modifications. It
has a range of influences on nuclear functions including epigenetic inheritance …
has a range of influences on nuclear functions including epigenetic inheritance …
[HTML][HTML] Advances in histone demethylase KDM3A as a cancer therapeutic target
J Yoo, YH Jeon, HY Cho, SW Lee, GW Kim, DH Lee… - Cancers, 2020 - mdpi.com
Lysine-specific histone demethylase 3 (KDM3) subfamily proteins are H3K9me2/me1
histone demethylases that promote gene expression. The KDM3 subfamily primarily consists …
histone demethylases that promote gene expression. The KDM3 subfamily primarily consists …
[HTML][HTML] Functions and interactions of mammalian KDM5 demethylases
E Pavlenko, T Ruengeler, P Engel, S Poepsel - Frontiers in genetics, 2022 - frontiersin.org
Mammalian histone demethylases of the KDM5 family are mediators of gene expression
dynamics during developmental, cellular differentiation, and other nuclear processes. They …
dynamics during developmental, cellular differentiation, and other nuclear processes. They …
The role of the histone demethylase KDM4A in cancer
L Guerra-Calderas, R González-Barrios, LA Herrera… - Cancer genetics, 2015 - Elsevier
Histone posttranslational modifications are important components of epigenetic regulation.
One extensively studied modification is the methylation of lysine residues. These …
One extensively studied modification is the methylation of lysine residues. These …
[HTML][HTML] Diverse functions of KDM5 in cancer: Transcriptional repressor or activator?
Y Ohguchi, H Ohguchi - Cancers, 2022 - mdpi.com
Simple Summary Aberrations in epigenetic modulators have been widely identified in
cancer; therefore, these modulators are attractive targets for cancer treatment. KDM5 is an …
cancer; therefore, these modulators are attractive targets for cancer treatment. KDM5 is an …
[HTML][HTML] KDM4B: a nail for every hammer?
C Wilson, AJ Krieg - Genes, 2019 - mdpi.com
Epigenetic changes are well-established contributors to cancer progression and normal
developmental processes. The reversible modification of histones plays a central role in …
developmental processes. The reversible modification of histones plays a central role in …