Motivation Histones form octameric complexes called nucleosomes, which organize the
genomic DNA of eukaryotes into chromatin. Each nucleosome comprises two copies each of …

Across the tree of life, DNA in living cells is associated with proteins that coat chromosomes,
constrain their structure and influence DNA-templated processes such as transcription and …

Genome organization and compaction in Archaea involves different chromatin proteins,
among which homologues of eukaryotic histones. Archaeal histones are considered the …

Nucleosomes restrict DNA accessibility throughout eukaryotic genomes, with repercussions
for replication, transcription, and other DNA-templated processes. How this globally …

Histones and associated chromatin proteins have essential functions in eukaryotic genome
organization and regulation. Despite this fundamental role in eukaryotic cell biology, we lack …

Histones are the principal constituents of chromatin in eukaryotes and most archaea, while
bacteria generally rely on an orthogonal set of proteins to organize their chromosomes …

Histone sequences have been identified in many archaeal genomes and in environmental
samples, and they constitute a family of proteins that are structural homologs of the …

The eukaryotic nucleosome is the fundamental unit of chromatin, comprising a protein
octamer that wraps∼ 147 bp of DNA and has essential roles in DNA compaction, replication …

In archaea, histones play a role in genome compaction and are involved in transcription
regulation. Whereas archaeal histones bind DNA without sequence specificity, they bind …

ABSTRACT DNA-binding proteins with roles in chromatin architecture and transcriptional
regulation are present in all three domains of life. Histones package DNA and regulate gene …