ABSTRACT NEQ288, one of two archaeal histones in Nanoarchaeum equitans, has a
unique four-residue insertion that closely resembles an insertion in the eukaryotic histone …

Protein-based compaction of the genome is a feature found in species across the tree of life.
In Archaea, the majority of species contain a histone fold domain-containing protein, and …

How did the nucleosome, the fundamental building block of all eukaryotic chromatin,
evolve? This central question has been impossible to address because the four core …

Genome regulation in eukaryotes revolves around the nucleosome, the fundamental
building block of eukaryotic chromatin. Its constituent parts, the four core histones (H3, H4 …

With the continuously accelerating genome sequencing from diverse groups of archaea and
bacteria, accurate identification of gene orthology and availability of readily expandable …

The histone proteins defining nucleosome structure are highly conserved in common model
organisms and are frequently portrayed as uniform chromatin building blocks. We surveyed …

Histone proteins compact and stabilize the genomes of Eukarya and Archaea. By forming
nucleosome (-like) structures they restrict access of DNA-binding transcription regulators to …

The archaeal genome is organized by either eukaryotic-like histone proteins or bacterial-like
nucleoid-associated proteins. Recent studies have revealed novel insights into chromatin …

Histone H1 variants, known as linker histones, are essential chromatin components in
higher eukaryotes, yet compared to the core histones relatively little is known about their in …

Genomic organization impacts accessibility and movement of information processing
systems along DNA. DNA-bound proteins dynamically dictate gene expression and provide …