The compartmentalization of proteins within the nucleus or cytoplasm of a eukaryotic cell
offers opportunity for regulation of cell cycle progression and signalling pathways. Nuclear …

In eukaryotic cells, the physical separation of the genetic material in the nucleus from the
translation and signaling machinery in the cytoplasm by the nuclear envelope creates a …

Many important regulatory proteins, including cell cycle regulators and transcription factors,
contain a phosphorylation site within or adjacent to a classic nuclear localization signal …

Signaling pathways consist of a chain of biochemical events that form the intracellular
equivalent of a fire bucket brigade. An initial change or chemical signal outside the cell is …

The concept of a nuclear targeting signal was¢ rst suggested more than 20 years ago by
studies of nuclear proteins in Xenopus oocytes [1]. Subsequent analyses identi¢ ed what we …

After synthesis in the cytoplasm, nuclear proteins traverse the nuclear envelope as a result
of the specific recognition of nuclear localization signals by import. Various approaches …

Phosphorylation is the most common and pleiotropic modification in biology, which plays a
vital role in regulating and finely tuning a multitude of biological pathways. Transport across …

The past two years have seen a significant increase in our understanding of nuclear protein
import. Five cytosolic import factors have been identified, two of which have been shown to …

The nuclear–cytoplasmic protein transport is a critical process in cellular events. The
identification of transport signals (nuclear localization signal and nuclear export signal) and …

In eukaryotic cells, cell functions are maintained in an orderly manner through the
continuous traffic of various proteins between the cell nucleus and the cytoplasm. The …