Dysregulation of placental lipid hydrolysis by high-fat/high-cholesterol feeding and gestational diabetes mellitus in mice

KB Kuentzel, I Bradić, ZN Mihalič, M Korbelius… - International Journal of …, 2022 - mdpi.com
Advanced maternal age and obesity are the main risk factors to develop gestational
diabetes mellitus (GDM). Obesity is a consequence of the increased storage of …

Placental lipases in pregnancies complicated by gestational diabetes mellitus (GDM)

HL Barrett, MH Kubala, K Scholz Romero, KJ Denny… - PLoS …, 2014 - journals.plos.org
Infants of women with gestational diabetes mellitus (GDM) are more likely to be born large
for gestational age with a higher percentage body fat. Elevated maternal lipids may …

Placental triglyceride accumulation in maternal type 1 diabetes is associated with increased lipase gene expression

MLS Lindegaard, P Damm, ER Mathiesen… - Journal of lipid …, 2006 - ASBMB
Maternal diabetes can cause fetal macrosomia and increased risk of obesity, diabetes, and
cardiovascular disease in adulthood of the offspring. Although increased transplacental lipid …

Effect of maternal triglycerides and free fatty acids on placental LPL in cultured primary trophoblast cells and in a case of maternal LPL deficiency

AL Magnusson-Olsson, S Lager… - American Journal …, 2007 - journals.physiology.org
Maternal hypertriglyceridemia is a normal condition in late gestation and is an adaptation to
ensure an adequate nutrient supply to the fetus. Placental lipoprotein lipase (LPL) is …

Placental lipoprotein lipase activity is positively associated with newborn adiposity

MJR Heerwagen, DL Gumina, TL Hernandez… - Placenta, 2018 - Elsevier
Introduction Recent data suggest that in addition to glucose, fetal growth is related to
maternal triglycerides (TG). To reach the fetus, TG must be hydrolyzed to free fatty acids …

The effect of high glucose on lipid metabolism in the human placenta

CH Hulme, A Nicolaou, SA Murphy, AEP Heazell… - Scientific reports, 2019 - nature.com
Diabetes mellitus (DM) during pregnancy can result in fetal overgrowth, likely due to
placental dysfunction, which has health consequences for the infant. Here we test our …

Maternal high-fat feeding increases placental lipoprotein lipase activity by reducing SIRT1 expression in mice

L Qiao, Z Guo, C Bosco, S Guidotti, Y Wang… - Diabetes, 2015 - Am Diabetes Assoc
This study investigated how maternal overnutrition and obesity regulate expression and
activation of proteins that facilitate lipid transport in the placenta. To create a maternal …

Insulin treatment may alter fatty acid carriers in placentas from gestational diabetes subjects

M Ruiz-Palacios, MT Prieto-Sánchez… - International Journal of …, 2017 - mdpi.com
There is little information available on the effect of Gestational diabetes mellitus (GDM)
treatment (diet or insulin) on placental lipid carriers, which may influence fetal fat accretion …

Impact of maternal circulating cholesterol and gestational diabetes mellitus on lipid metabolism in human term placenta

C Marseille‐Tremblay… - Molecular …, 2008 - Wiley Online Library
Maternal hypercholesterolemia (HC) during pregnancy and gestational diabetes mellitus
(GDM) are associated with disturbance of fetal development which may also modify key …

Gestational diabetes mellitus modulates cholesterol homeostasis in human fetoplacental endothelium

Y Sun, S Kopp, J Strutz, CC Gali, M Zandl-Lang… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Gestational diabetes mellitus (GDM) is associated with excessive oxidative stress which may
affect placental vascular function. Cholesterol homeostasis is crucial for maintaining …