Dysregulation of placental lipid hydrolysis by high-fat/high-cholesterol feeding and gestational diabetes mellitus in mice
KB Kuentzel, I Bradić, ZN Mihalič, M Korbelius… - International Journal of …, 2022 - mdpi.com
Advanced maternal age and obesity are the main risk factors to develop gestational
diabetes mellitus (GDM). Obesity is a consequence of the increased storage of …
diabetes mellitus (GDM). Obesity is a consequence of the increased storage of …
Placental lipases in pregnancies complicated by gestational diabetes mellitus (GDM)
Infants of women with gestational diabetes mellitus (GDM) are more likely to be born large
for gestational age with a higher percentage body fat. Elevated maternal lipids may …
for gestational age with a higher percentage body fat. Elevated maternal lipids may …
Placental triglyceride accumulation in maternal type 1 diabetes is associated with increased lipase gene expression
MLS Lindegaard, P Damm, ER Mathiesen… - Journal of lipid …, 2006 - ASBMB
Maternal diabetes can cause fetal macrosomia and increased risk of obesity, diabetes, and
cardiovascular disease in adulthood of the offspring. Although increased transplacental lipid …
cardiovascular disease in adulthood of the offspring. Although increased transplacental lipid …
Effect of maternal triglycerides and free fatty acids on placental LPL in cultured primary trophoblast cells and in a case of maternal LPL deficiency
AL Magnusson-Olsson, S Lager… - American Journal …, 2007 - journals.physiology.org
Maternal hypertriglyceridemia is a normal condition in late gestation and is an adaptation to
ensure an adequate nutrient supply to the fetus. Placental lipoprotein lipase (LPL) is …
ensure an adequate nutrient supply to the fetus. Placental lipoprotein lipase (LPL) is …
Placental lipoprotein lipase activity is positively associated with newborn adiposity
MJR Heerwagen, DL Gumina, TL Hernandez… - Placenta, 2018 - Elsevier
Introduction Recent data suggest that in addition to glucose, fetal growth is related to
maternal triglycerides (TG). To reach the fetus, TG must be hydrolyzed to free fatty acids …
maternal triglycerides (TG). To reach the fetus, TG must be hydrolyzed to free fatty acids …
The effect of high glucose on lipid metabolism in the human placenta
Diabetes mellitus (DM) during pregnancy can result in fetal overgrowth, likely due to
placental dysfunction, which has health consequences for the infant. Here we test our …
placental dysfunction, which has health consequences for the infant. Here we test our …
Maternal high-fat feeding increases placental lipoprotein lipase activity by reducing SIRT1 expression in mice
L Qiao, Z Guo, C Bosco, S Guidotti, Y Wang… - Diabetes, 2015 - Am Diabetes Assoc
This study investigated how maternal overnutrition and obesity regulate expression and
activation of proteins that facilitate lipid transport in the placenta. To create a maternal …
activation of proteins that facilitate lipid transport in the placenta. To create a maternal …
Insulin treatment may alter fatty acid carriers in placentas from gestational diabetes subjects
M Ruiz-Palacios, MT Prieto-Sánchez… - International Journal of …, 2017 - mdpi.com
There is little information available on the effect of Gestational diabetes mellitus (GDM)
treatment (diet or insulin) on placental lipid carriers, which may influence fetal fat accretion …
treatment (diet or insulin) on placental lipid carriers, which may influence fetal fat accretion …
Impact of maternal circulating cholesterol and gestational diabetes mellitus on lipid metabolism in human term placenta
C Marseille‐Tremblay… - Molecular …, 2008 - Wiley Online Library
Maternal hypercholesterolemia (HC) during pregnancy and gestational diabetes mellitus
(GDM) are associated with disturbance of fetal development which may also modify key …
(GDM) are associated with disturbance of fetal development which may also modify key …
Gestational diabetes mellitus modulates cholesterol homeostasis in human fetoplacental endothelium
Y Sun, S Kopp, J Strutz, CC Gali, M Zandl-Lang… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Gestational diabetes mellitus (GDM) is associated with excessive oxidative stress which may
affect placental vascular function. Cholesterol homeostasis is crucial for maintaining …
affect placental vascular function. Cholesterol homeostasis is crucial for maintaining …