Cardiovascular disease in patients with chronic inflammation: mechanisms underlying premature cardiovascular events in rheumatologic conditions

JC Mason, P Libby - European heart journal, 2015 - academic.oup.com
A variety of systemic inflammatory rheumatic diseases associate with an increased risk of
atherosclerotic events and premature cardiovascular (CV) disease. Although this recognition …

Explaining how “high-grade” systemic inflammation accelerates vascular risk in rheumatoid arthritis

N Sattar, DW McCarey, H Capell, IB McInnes - Circulation, 2003 - Am Heart Assoc
There is intense interest in mechanisms whereby low-grade inflammation could interact with
conventional and novel vascular risk factors to promote the atheromatous lesion. Patients …

Atherosclerosis and inflammation: insights from rheumatoid arthritis

CP Chung, I Avalos, P Raggi, CM Stein - Clinical rheumatology, 2007 - Springer
Cardiovascular disease is a major health care problem and the most common cause of
death among individuals from developed nations. Our understanding of atherosclerosis has …

Cardiovascular co-morbidity in rheumatic diseases

C Turesson, LTH Jacobsson… - Vascular health and risk …, 2008 - Taylor & Francis
Patients with rheumatic disorders have an increased risk of cardiovascular disease (CVD).
This excess co-morbidity is not fully explained by traditional risk factors. Disease severity is a …

Rheumatoid arthritis a model of systemic inflammation driving atherosclerosis

IA Ku, JB Imboden, PY Hsue, P Ganz - Circulation Journal, 2009 - jstage.jst.go.jp
Similarities between the inflammatory pathways in atherosclerosis and rheumatoid arthritis
(RA) are striking. Chronic systemic inflammation in RA patients leads to cardiovascular (CV) …

The rationale for comparative studies of accelerated atherosclerosis in rheumatic diseases

A Yuri Gasparyan… - Current vascular …, 2010 - ingentaconnect.com
The inflammatory pathogenesis of atherosclerosis is now well-established, owing to in vitro
and in vivo studies and the application of high sensitivity assays for C-reactive protein (CRP) …

Atherosclerosis in rheumatoid arthritis: is it all about inflammation?

S Skeoch, IN Bruce - Nature Reviews Rheumatology, 2015 - nature.com
Rheumatoid arthritis (RA) has long been associated with increased cardiovascular risk, but
despite substantial improvements in disease management, mortality remains high …

Rheumatoid arthritis and cardiovascular disease: the role of systemic inflammation and evolving strategies of prevention

MH Snow, TR Mikuls - Current opinion in rheumatology, 2005 - journals.lww.com
The pathogenesis of cardiovascular disease in rheumatoid arthritis is complex and involves
several intermediate factors, including dyslipidemia, elevations in serum homocysteine …

Cardiovascular risk in rheumatoid arthritis: recent advances in the understanding of the pivotal role of inflammation, risk predictors and the impact of treatment

E Choy, K Ganeshalingam, AG Semb… - …, 2014 - academic.oup.com
Risk of cardiovascular (CV) disease is increased among RA patients. High inflammatory
burden associated with RA appears to be a key driver of the increased cardiovascular risk …

Inflammation and atherosclerosis in rheumatoid arthritis

RJ Stevens, KMJ Douglas, AN Saratzis… - Expert reviews in …, 2005 - cambridge.org
Rheumatoid arthritis (RA) associates with increased cardiovascular mortality. This appears
to be predominantly due to ischaemic causes, such as myocardial infarction and congestive …