The past year has witnessed substantial advances in understanding the genetic basis of
many common phenotypes of biomedical importance. These advances have been the result …

Genomewide Association Studies — Illuminating Biologic Pathways | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Following the identification of several disease-associated polymorphisms by genome-wide
association (GWA) analysis, interest is now focusing on the detection of effects that, owing to …

Small effect sizes, common-disease/common-variant versus rare variant influences, biased
single nucleotide polymorphism ascertainment and low linkage disequilibrium have recently …

Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

After nearly 10 years of intense academic and commercial research effort, large genome-
wide association studies for common complex diseases are now imminent. Although these …

Genomewide association studies have been advocated as a promising alternative to
genomewide linkage scans for detection of small-effect genes in complex diseases …

Although genome-wide association studies (GWASs) have identified thousands of risk loci
for many complex traits and diseases, the causal variants and genes at these loci remain …

Large-scale association studies hold substantial promise for unraveling the genetic basis of
common human diseases. A well-known problem with such studies is the presence of …

There are thousands of known associations between genetic variants and complex human
phenotypes, and the rate of novel discoveries is rapidly increasing. Translating those …