Genome-wide gene and pathway analysis
Current GWAS have primarily focused on testing association of single SNPs. To only test for
association of single SNPs has limited utility and is insufficient to dissect the complex …
association of single SNPs has limited utility and is insufficient to dissect the complex …
Adjusting for heritable covariates can bias effect estimates in genome-wide association studies
In recent years, a number of large-scale genome-wide association studies have been
published for human traits adjusted for other correlated traits with a genetic basis. In most …
published for human traits adjusted for other correlated traits with a genetic basis. In most …
Gene–environment-wide association studies: emerging approaches
D Thomas - Nature reviews genetics, 2010 - nature.com
Despite the yield of recent genome-wide association (GWA) studies, the identified variants
explain only a small proportion of the heritability of most complex diseases. This …
explain only a small proportion of the heritability of most complex diseases. This …
Genome-wide association studies in diverse populations
NA Rosenberg, L Huang, EM Jewett… - Nature Reviews …, 2010 - nature.com
Genome-wide association (GWA) studies have identified a large number of SNPs
associated with disease phenotypes. As most GWA studies have been performed in …
associated with disease phenotypes. As most GWA studies have been performed in …
A plethora of pleiotropy across complex traits
PM Visscher, J Yang - Nature genetics, 2016 - nature.com
A new analysis has identified hundreds of loci that are associated with multiple traits or
diseases by comparing genome-wide association study (GWAS) data for 42 complex traits …
diseases by comparing genome-wide association study (GWAS) data for 42 complex traits …
CAUSALdb: a database for disease/trait causal variants identified using summary statistics of genome-wide association studies
Genome-wide association studies (GWASs) have revolutionized the field of complex trait
genetics over the past decade, yet for most of the significant genotype-phenotype …
genetics over the past decade, yet for most of the significant genotype-phenotype …
Phenotypic complexity, measurement bias, and poor phenotypic resolution contribute to the missing heritability problem in genetic association studies
Background The variance explained by genetic variants as identified in (genome-wide)
genetic association studies is typically small compared to family-based heritability estimates …
genetic association studies is typically small compared to family-based heritability estimates …
Biological interpretation of genome-wide association studies using predicted gene functions
The main challenge for gaining biological insights from genetic associations is identifying
which genes and pathways explain the associations. Here we present DEPICT, an …
which genes and pathways explain the associations. Here we present DEPICT, an …
SNP discovery in associating genetic variation with human disease phenotypes
Y Suh, J Vijg - … Research/Fundamental and Molecular Mechanisms of …, 2005 - Elsevier
With the completion of the human genome project, attention is now rapidly shifting towards
the study of individual genetic variation. The most abundant source of genetic variation in …
the study of individual genetic variation. The most abundant source of genetic variation in …
Validating, augmenting and refining genome-wide association signals
JPA Ioannidis, G Thomas, MJ Daly - Nature Reviews Genetics, 2009 - nature.com
Studies using genome-wide platforms have yielded an unprecedented number of promising
signals of association between genomic variants and human traits. This Review addresses …
signals of association between genomic variants and human traits. This Review addresses …