Recent genome-wide association studies (GWAS) have identified DNA sequence variations
that exhibit unequivocal statistical associations with many common chronic diseases …

Genetic studies have identified thousands of variants associated with complex traits.
However, most association studies are limited to populations of European descent and a …

Genome-wide association (GWA) studies have typically focused on the analysis of single
markers, which often lacks the power to uncover the relatively small effect sizes conferred by …

Genome-wide association studies (GWASs) have created a paradigm shift in discovering
genetic associations for common diseases and phenotypes, but it is unclear whether the …

Genome-wide association studies (GWAS) aim to identify genetic factors associated with
phenotypes. Standard analyses test variants for associations individually. However, variant …

Association studies with candidate genes have been widely used for the study of complex
diseases. However, this approach has been criticized because of non-replication of results …

Many gene–disease associations proposed to date have not been consistently replicated
across different populations. Nonreplication often reflects false positives in the original …

The advent of the first wave of genome-wide association studies (GWAS) provided a new
conceptual framework in the search for variants underlying common disorders: a massive …

Genome-wide association studies (GWAS) have identified hundreds of genetic variants
associated with complex traits and diseases. However, elucidating the causal genes …

Several recent papers have used summary results from genome-wide association studies to
characterize genetic overlap between human complex traits and common diseases. The …