Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins
CRISPR loci and Cas proteins provide adaptive immunity in prokaryotes against invading
bacteriophages and plasmids. In response, bacteriophages have evolved a broad spectrum …
bacteriophages and plasmids. In response, bacteriophages have evolved a broad spectrum …
Keeping crispr in check: diverse mechanisms of phage-encoded anti-crisprs
D Trasanidou, AS Geros, P Mohanraju… - FEMS microbiology …, 2019 - academic.oup.com
ABSTRACT CRISPR-Cas represents the only adaptive immune system of prokaryotes
known to date. These immune systems are widespread among bacteria and archaea, and …
known to date. These immune systems are widespread among bacteria and archaea, and …
[HTML][HTML] Structural insights into the inactivation of CRISPR-Cas systems by diverse anti-CRISPR proteins
Y Zhu, F Zhang, Z Huang - BMC biology, 2018 - Springer
A molecular arms race is progressively being unveiled between prokaryotes and viruses.
Prokaryotes utilize CRISPR-mediated adaptive immune systems to kill the invading phages …
Prokaryotes utilize CRISPR-mediated adaptive immune systems to kill the invading phages …
Structural basis of CRISPR-Cas Type III prokaryotic defence systems
R Molina, N Sofos, G Montoya - Current opinion in structural biology, 2020 - Elsevier
Highlights•Type III is the most diverse and complex CRISPR-Cas system.•Type III CRISPR-
Cas systems cleave RNA and DNA.•The effector complexes generate secondary …
Cas systems cleave RNA and DNA.•The effector complexes generate secondary …
Disabling a type IE CRISPR-Cas nuclease with a bacteriophage-encoded anti-CRISPR protein
ABSTRACT CRISPR (clustered regularly interspaced short palindromic repeat)-Cas
adaptive immune systems are prevalent defense mechanisms in bacteria and archaea. They …
adaptive immune systems are prevalent defense mechanisms in bacteria and archaea. They …
The discovery, mechanisms, and evolutionary impact of anti-CRISPRs
AL Borges, AR Davidson… - Annual review of …, 2017 - annualreviews.org
Bacteria and archaea use CRISPR-Cas adaptive immune systems to defend themselves
from infection by bacteriophages (phages). These RNA-guided nucleases are powerful …
from infection by bacteriophages (phages). These RNA-guided nucleases are powerful …
[HTML][HTML] A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses
J Wang, J Ma, Z Cheng, X Meng, L You, M Wang… - Cell research, 2016 - nature.com
CRISPR/Cas systems are widespread RNA-mediated prokaryotic adaptive immune systems
providing protection against invading nucleic acids [1]. However, throughout evolution, this …
providing protection against invading nucleic acids [1]. However, throughout evolution, this …
Anti-CRISPRs: protein inhibitors of CRISPR-Cas systems
AR Davidson, WT Lu, SY Stanley… - Annual review of …, 2020 - annualreviews.org
Clustered regularly interspaced short palindromic repeats (CRISPR) together with their
accompanying cas (CRISPR-associated) genes are found frequently in bacteria and …
accompanying cas (CRISPR-associated) genes are found frequently in bacteria and …
The basic building blocks and evolution of CRISPR–Cas systems
KS Makarova, YI Wolf, EV Koonin - Biochemical Society …, 2013 - portlandpress.com
CRISPR (clustered regularly interspaced short palindromic repeats)–Cas (CRISPR-
associated) is an adaptive immunity system in bacteria and archaea that functions via a …
associated) is an adaptive immunity system in bacteria and archaea that functions via a …
[PDF][PDF] Biology and applications of CRISPR systems: harnessing nature's toolbox for genome engineering
Bacteria and archaea possess a range of defense mechanisms to combat plasmids and viral
infections. Unique among these are the CRISPR-Cas (clustered regularly interspaced short …
infections. Unique among these are the CRISPR-Cas (clustered regularly interspaced short …