[HTML][HTML] Multi-omic analysis in a metabolic syndrome porcine model implicates arachidonic acid metabolism disorder as a risk factor for atherosclerosis

SS Xu, XL Zhang, SS Liu, ST Feng, GM Xiang… - Frontiers in …, 2022 - frontiersin.org
Background The diet-induced gut microbiota dysbiosis has been suggested as a major risk
factor for atherothrombosis, however, the detailed mechanism linking these conditions is yet …

Gut microbiome of a porcine model of metabolic syndrome and HF-pEF

AN O'Donovan, FM Herisson, F Fouhy… - American Journal …, 2020 - journals.physiology.org
Metabolic syndrome (MetS) is a composite of cardiometabolic risk factors, including obesity,
dyslipidemia, hypertension, and insulin resistance, with a range of secondary sequelae such …

Changes in the mucosa-associated microbiome and transcriptome across gut segments are associated with obesity in a metabolic syndrome porcine model

SS Xu, N Wang, L Huang, XL Zhang… - Microbiology …, 2022 - Am Soc Microbiol
Several studies have suggested a role for gut mucosa-associated microbiota in the
development of obesity, but the mechanisms involved are poorly defined. Here, the impact of …

Interplay between diet, the gut microbiome, and atherosclerosis: Role of dysbiosis and microbial metabolites on inflammation and disordered lipid metabolism

L Anto, CN Blesso - The Journal of Nutritional Biochemistry, 2022 - Elsevier
Atherosclerosis remains the leading cause of death worldwide. Lifestyle modification,
including diet and exercise, is recommended to be the primary prevention strategy for …

[HTML][HTML] Gut microbiota and metabolic syndrome

PX Wang, XR Deng, CH Zhang… - Chinese Medical …, 2020 - journals.lww.com
Metabolic syndrome (MetS) describes a set of risk factors that can eventually lead to the
occurrence of cardiovascular and cerebrovascular disease. A detailed understanding of the …

[HTML][HTML] Gut microbiota-mediated secondary bile acid alleviates Staphylococcus aureus-induced mastitis through the TGR5-cAMP-PKA-NF-κB/NLRP3 pathways in …

C Zhao, K Wu, H Hao, Y Zhao, L Bao, M Qiu… - NPJ biofilms and …, 2023 - nature.com
Although emerging evidence shows that gut microbiota-mediated metabolic changes
regulate intestinal pathogen invasions, little is known about whether and how gut microbiota …

[HTML][HTML] Cross-omics analysis revealed gut microbiome-related metabolic pathways underlying atherosclerosis development after antibiotics treatment

BA Kappel, L De Angelis, M Heiser, M Ballanti… - Molecular …, 2020 - Elsevier
Objective The metabolic influence of gut microbiota plays a pivotal role in the pathogenesis
of cardiometabolic diseases. Antibiotics affect intestinal bacterial diversity, and long-term …

The gut microbiome dysbiosis is recovered by restoring a normal diet in hypercholesterolemic pigs

L Schoch, P Sutelman, R Suades… - European Journal of …, 2023 - Wiley Online Library
Background Gut microbiota is thought to modulate cardiovascular risk. However, the effect of
cardiovascular primary prevention strategies on gut microbiota remains largely unknown …

[HTML][HTML] Multiomics analysis investigating the impact of a high-fat diet in female Sprague–Dawley rats: alterations in plasma, intestinal metabolism, and microbial …

J Zhang, B Hu, X Deng, R Sun, R Zhang, K Chen… - Frontiers in …, 2024 - frontiersin.org
Introduction With improvements in living conditions, modern individuals exhibit a
pronounced inclination towards a high-fat diet, largely because of its distinctive gustatory …

[HTML][HTML] Differential Response of Ileal and Colonic Microbiota in Rats with High-Fat Diet-Induced Atherosclerosis

L Wen, W Xiong, G Wei, L Zhang, Y Liu… - International Journal of …, 2022 - mdpi.com
Growing evidence suggests that gut microbiota are associated with atherosclerosis (AS).
However, the functional heterogeneity of each gut segment gives rise to regional differences …