The overconsumption of both saturated fats and fructose in the modern society has been
related to the development of nonalcoholic fatty liver disease (NAFLD). However, the …

High fructose flux enhances hepatocellular triglyceride accumulation (hepatic steatosis),
which is a prime trigger in the emergence of hepatic ailments. Nevertheless, the …

Obesity is accompanied by a low-grade inflammation state, characterized by increased
proinflammatory cytokines levels such as tumor necrosis factor alpha (TNFα) and interleukin …

Abstract Non-Alcoholic Fatty Liver Disease (NAFLD) represents the most common form of
chronic liver injury and can progress to cirrhosis and hepatocellular carcinoma. A “multi-hit” …

Changes of lipidic storage, oxidative stress and mitochondrial dysfunction may be involved
in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Although the knowledge of …

Background The transcription factor nuclear factor-E2-related factor-2 (Nrf2) inhibits lipid
accumulation and oxidative stress in the liver by interfering with lipogenic pathways and …

Nonalcoholic fatty liver disease is characterized by an abnormal accumulation of
triacylglycerides in the liver in absence of significant alcohol consumption. Under these …

Oxidative stress is implicated in the development of non-alcoholic steatohepatitis (NASH).
The Nrf2-antioxidant response element pathway protects cells from oxidative stress. Studies …

The activation of NOD-like receptor family pyrin domain containing 3 (NLRP3)
inflammasome is closely associated with the development and progression of non-alcoholic …

The Nod‐like receptor protein 3 (NLRP3) inflammasome activation not only serves as an
intracellular machinery triggering inflammation but also produces uncanonical effects …