Effect of dopamine agonists and antagonists on ethanol-reinforced behavior: the involvement of the nucleus accumbens

HH Samson, CW Hodge, GA Tolliver, M Haraguchi - Brain research bulletin, 1993 - Elsevier
Rats initiated to self-administer 10% ethanol (v/v) in an operant situation using the sucrose-
substitution technique received bilateral n. accumbens or caudate nucleus microinjections of …

Microinjections of dopamine agonists in the nucleus accumbens increase ethanol-reinforced responding

CW Hodge, HH Samson, M Haraguchi - Pharmacology Biochemistry and …, 1992 - Elsevier
Abstract Long-Evans rats (N= 3) were trained to lever press on a fixed-ratio 4 (FR 4)
schedule with ethanol (10% v/v) presented as the reinforcer. Each rat received a total of six …

Effects of intraaccumbens injections of dopamine agonists and antagonists on sucrose and sucrose-ethanol reinforced responding

CW Hodge, HH Samson, GA Tolliver… - Pharmacology …, 1994 - Elsevier
The present experiment tested the effects of intraaccumbens injections of dopamine (DA)
agonists and antagonists on operant responding reinforced by sucrose and sucrose/ethanol …

Microinjections of dopaminergic agents in the nucleus accumbens affect ethanol consumption but not palatability

HJ Kaczmarek, SW Kiefer - Pharmacology Biochemistry and Behavior, 2000 - Elsevier
It was determined whether ethanol palatability in rats could be changed by manipulating the
reinforcement experienced during limited access consumption. During the first 3 days of the …

Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol.

A Imperato, G Di Chiara - Journal of Pharmacology and Experimental …, 1986 - ASPET
The effect of the ip administration of ethanol on the release of dopamine (DA) and on the
output of its main metabolites, dihydroxyphenylacetic acid and homovanillic acid, was …

Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants.

F Weiss, MT Lorang, FE Bloom, GF Koob - Journal of Pharmacology and …, 1993 - ASPET
Dopaminergic neurotransmission in the nucleus accumbens may be an important factor in
ethanol reinforcement and genetically determined ethanol preference. This hypothesis was …

The effects of 6-hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat

S Rassnick, L Stinus, GF Koob - Brain research, 1993 - Elsevier
Rats readily learn to self-administer ethanol using a procedure where ethanol is introduced
in the presence of a sweetener. After gradual removal of the sweetener, sufficient quantities …

Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus accumbens

S Rassnick, L Pulvirenti, GF Koob - Psychopharmacology, 1992 - Springer
The purpose of this study was to assess the role of endogenous dopamine and glutamate
systems within the nucleus accumbens in modulating responses for oral ethanol …

Alcohol self-administration: role of mesolimbic dopamine.

HH Samson, GA Tolliver, M Haraguchi… - Annals of the New York …, 1992 - europepmc.org
It appears clear that ethanol reinforcement, like that of many abused drugs, utilizes the
mesolimbic DA pathways. From the data presented on microinjection of DA agonists and …

Changes in the sensitivity of dopamine receptors in the nucleus accumbens and in the striatum induced by chronic ethanol administration

S Liljequist - Acta Pharmacologica et Toxicologica, 1978 - Wiley Online Library
Abstract Rats of the Sprague‐Dawley strain were maintained on ad libitum food and a forced‐
intake regimen of ethanol for up to 270 days. Bilateral application of dopamine (DA) into the …