Under conditions of hypoxia, most eukaryotic cells can shift their primary metabolic strategy
from predominantly mitochondrial respiration towards increased glycolysis to maintain ATP …

Hypoxia inducible factor-1 (HIF-1) is as a key transcriptional mediator of the hypoxic
response in eukaryotic cells, regulating the expression of a myriad of genes involved in …

Abstract Hypoxia-inducible factor 1 (HIF-1) mediates transcriptional responses to hypoxia.
HIF-1 is composed of an O2-and growth factor-regulated HIF-loc subunit and a constitutively …

Oxygen is essential for living organisms. Molecular oxygen binds to hemoglobin and is
delivered to every organ in the body. In several cardiovascular diseases or anemia, local …

The transcription factor HIF-1 is one of the principal mediators of homeostasis in human
tissues exposed to hypoxia. It is implicated in virtually every process of rapid gene …

Hypoxia inducible factors (HIFs) are transcription factors, which are commonly expressed in
mammals, including humans. The HIFs consist of hypoxia-regulated α and oxygen …

The heterodimeric transcription factor hypoxia-inducible factor-1 (HIF-1) is activated under
hypoxic conditions, resulting in the upregulation of its target genes plasminogen activator …

Hypoxia plays a major role in the induction of angiogenesis during tumor development. One
mechanism by which tumor cells respond to a reduced oxygen level is via the activation of …

Local oxygen tension has a profound effect on the vasculature, which compensates vascular
insufficiency through the induction of angiogenesis. An important mediator in this process is …

Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that functions as a master
regulator of O2 homeostasis. HIF-1 target genes encode proteins that increase O2 delivery …