Objective: Since the effects of angiotensin II receptor antagonism on arterial function in nitric
oxide (NO)-deficient hypertension are unknown, we investigated the influence of losartan …

We previously succeeded in measuring the nitrosylhemoglobin (HbNO) level as an index of
blood nitric oxide (NO) by the electron paramagnetic resonance (EPR) HbNO signal …

The objective of this study was to examine the effects of long-term antihypertensive therapy
on blood pressure and vascular responses of resistance arteries during prolonged inhibition …

Nitric oxide (NO) is a tonically produced vasodilator that maintains blood pressure (BP) in
the normal animal. In these studies, we produced chronic NO blockade by oral …

The responsiveness of isolated high-pressure (aorta, renal artery) and low-pressure vessels
(pulmonary artery) was compared during systemic hypertension induced by chronic …

Objective To determine whether the abnormal vascular responses observed in salt-sensitive
hypertension are caused by an impairment in vascular nitric oxide function. Design Isometric …

Background Inhibition of nitric oxide (NO) synthase by l-arginine analogs is associated with
elevation of blood pressure in rats. Because endothelium-dependent vasomotion in different …

BACKGROUND Patients with essential hypertension have abnormal endothelium-
dependent vasodilation. Because the endothelium exerts its action on the vascular smooth …

While the effect of chronic non-specific NO-synthase inhibition in the cardiovascular system
has been recognized under normotensive and hypertensive conditions, there are no data …

Objective: A decreased responsiveness to endothelium-dependent vasodilatory substances
is characteristically seen in isolated arteries from spontaneously hypertensive rats (SHR) …