Preclinical and clinical studies conducted in the mid-1990s reported strong association and
causality between the T-cell helper (TH) 1 inductor cytokine interleukin (IL)-12 and …

Abstract The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell–
mediated responses in inflammation for more than a decade after it was first identified …

Interleukin (IL)‐12 and IL‐23 are related cytokines that have been implicated in the
pathogenesis of several immune‐mediated disorders. IL‐12 and IL‐23 are heterodimers …

Monoclonal antibody (mAb) therapy was first established upon the approval of a mouse
antibody for treatment of human acute organ rejection. However, the high incidence of …

IL-23 is a pro-inflammatory cytokine belonging to the IL-12 cytokine family. IL-23 is essential
for the differentiation of Th17 lymphocytes, a subtype of T lymphocyte implicated in chronic …

Interleukin (IL)-12 and IL-23 are heterodimeric proinflammatory cytokines that share a
common p40 subunit, paired with p35 and p19 subunits, respectively. They represent an …

Targeting pro-inflammatory cytokines such as tumour necrosis factor-α (TNF-α) has been an
effective therapeutic approach in patients with a variety of autoimmune diseases, including …

Psoriasis is a chronic relapsing immunoinflammatory dermatosis that is commonly
associated with systemic comorbidities. The pathogenic importance of interleukin (IL)-12 …

The key role of interleukin-17 (IL-17) and T helper 17 (TH17) cells in tissue inflammation,
autoimmunity and host defence led to the experimental targeting of these molecules in …

Abstract Interleukin (IL)-12 and IL-23 play important roles in the development of
experimental autoimmune disease models and numerous afflictions affecting humans …