Heterogeneous antimicrobial susceptibility characteristics in Pseudomonas aeruginosa isolates from cystic fibrosis patients

X Qin, C Zhou, DM Zerr, A Adler, A Addetia, S Yuan… - MSphere, 2018 - Am Soc Microbiol
Clinical isolates of Pseudomonas aeruginosa from patients with cystic fibrosis (CF) are
known to differ from those associated with non-CF hosts by colony morphology, drug …

Genetic relatedness and host specificity of Pseudomonas aeruginosa isolates from cystic fibrosis and non-cystic fibrosis patients

A AbdulWahab, SJ Taj-Aldeen, E Ibrahim… - Infection and drug …, 2014 - Taylor & Francis
Background Pseudomonas aeruginosa is one of the primary pathogens isolated more
frequently in cystic fibrosis (CF) and it exhibits innate resistance to a wide range of …

The role of hypermutation and collateral sensitivity in antimicrobial resistance diversity of Pseudomonas aeruginosa populations in cystic fibrosis lung infection

J Vanderwoude, S Azimi, TD Read, SP Diggle - Mbio, 2024 - Am Soc Microbiol
Pseudomonas aeruginosa is an opportunistic pathogen which causes chronic, drug-
resistant lung infections in cystic fibrosis (CF) patients. In this study, we explore the role of …

Pseudomonas aeruginosa syntrophy in chronically colonized airways of cystic fibrosis patients

X Qin, DM Zerr, MA McNutt, JE Berry… - Antimicrobial agents …, 2012 - Am Soc Microbiol
Pseudomonas aeruginosa isolates from cystic fibrosis (CF) patients undergo remarkable
phenotypic divergence over time, including loss of pigmentation, hemolysis, motility, and …

[HTML][HTML] Phenotypic diversity within a Pseudomonas aeruginosa population infecting an adult with cystic fibrosis

ST Clark, J Diaz Caballero, M Cheang, B Coburn… - Scientific reports, 2015 - nature.com
Chronic airway infections caused by Pseudomonas aeruginosa contribute to the
progression of pulmonary disease in individuals with cystic fibrosis (CF). In the setting of CF …

Genomic characterisation of an international Pseudomonas aeruginosa reference panel indicates that the two major groups draw upon distinct mobile gene pools

L Freschi, C Bertelli, J Jeukens… - FEMS microbiology …, 2018 - academic.oup.com
Pseudomonas aeruginosa is an important opportunistic pathogen, especially in the context
of infections of cystic fibrosis (CF). In order to facilitate coordinated study of this pathogen, an …

[HTML][HTML] Phenotypic Heterogeneity of Pseudomonas aeruginosa Populations in a Cystic Fibrosis Patient

ML Workentine, CD Sibley, B Glezerson, S Purighalla… - PloS one, 2013 - journals.plos.org
The opportunistic pathogen Pseudomonas aeruginosa chronically infects the lower airways
of patients with cystic fibrosis. Throughout the course of infection this organism undergoes …

[HTML][HTML] The Population Genetics of Pseudomonas aeruginosa Isolates from Different Patient Populations Exhibits High-Level Host Specificity

R van Mansfeld, I Jongerden, M Bootsma, A Buiting… - PLoS …, 2010 - journals.plos.org
Objective To determine whether highly prevalent P. aeruginosa sequence types (ST) in
Dutch cystic fibrosis (CF) patients are specifically linked to CF patients we investigated the …

Pooling isolates to address the diversity in antimicrobial susceptibility of Pseudomonas aeruginosa in cystic fibrosis

S Van den Bossche, E Abatih, L Grassi… - Microbiology …, 2023 - Am Soc Microbiol
The intrasample diversity in antibiotic resistance of Pseudomonas aeruginosa in people with
cystic fibrosis (pwCF) may contribute to the low predictive value of antibiotic susceptibility …

Diversification of Pseudomonas aeruginosa within the cystic fibrosis lung and its effects on antibiotic resistance

ST Clark, DS Guttman, DM Hwang - FEMS microbiology letters, 2018 - academic.oup.com
The evolution and diversification of bacterial pathogens within human hosts represent
potential barriers to the diagnosis and treatment of life-threatening infections. Tremendous …