Rationale: During long-term lung infection in patients with cystic fibrosis (CF), Pseudomonas
aeruginosa strains develop mutations leading to clonal expansion. This microevolution is …

I read with great interest the recent publication by Auberbach and colleagues concerning the
potential clinical implications of hypermutable Pseudomonas aeruginosa in chronic …

Cystic fibrosis (CF) is a progressive autosomal recessive genetic disease that principally
affects the respiratory and digestive systems. It is a chronic disease that has no cure …

BACKGROUND: The identification of Pseudomonas aeruginosa (P. aeruginosa) isolates in
sputum from cystic fibrosis (CF) patients can be challenging due to the multitude of …

Over the last decade, epidemic and frequently multidrug-resistant Pseudomonas aeruginosa
has increasingly been found among European cystic fibrosis (CF) patients. In the Czech …

The ability to establish lifelong persistent infections is a fundamental aspect of the
interactions between many pathogenic microorganisms and their mammalian hosts. One …

Hypermutable Pseudomonas aeruginosa isolates (hypermutators) have been identified in
patients with cystic fibrosis (CF) and are associated with reduced lung function …

Background The primary cause of morbidity and mortality in cystic fibrosis (CF) patients is
lung infection by Pseudomonas aeruginosa. Therefore much work has been done to …

Chronic airway infections with Pseudomonas aeruginosa determine morbidity in most
individuals with cystic fibrosis (CF). P. aeruginosa may persist for decades in CF lungs …

Background Pseudomonas aeruginosa (PA) strains with defective DNA mismatch repair
genes generate numerous bacterial variants because of high mutation rates. In cystic …