Traffic of botulinum toxins A and E in excitatory and inhibitory neurons
C Verderio, C Grumelli, L Raiteri, S Coco, S Paluzzi… - Traffic, 2007 - Wiley Online Library
Botulinum neurotoxins (BoNTs), proteases specific for the SNARE proteins, are used to
study the molecular machinery supporting exocytosis and are used to treat human diseases …
study the molecular machinery supporting exocytosis and are used to treat human diseases …
Uptake of botulinum neurotoxin into cultured neurons
JE Keller, F Cai, EA Neale - Biochemistry, 2004 - ACS Publications
Botulinum neurotoxins (BoNTs) act within the synaptic terminal to block neurotransmitter
release. The toxin enters the neuron by binding to neuronal membrane receptor (s), being …
release. The toxin enters the neuron by binding to neuronal membrane receptor (s), being …
Association of botulinum neurotoxin serotypes a and B with synaptic vesicle protein complexes
MR Baldwin, JT Barbieri - Biochemistry, 2007 - ACS Publications
Botulinum neurotoxins (BoNTs) elicit flaccid paralysis through cleavage of SNARE proteins
within peripheral neurons. There are seven serotypes of the BoNTs, termed A− G, which …
within peripheral neurons. There are seven serotypes of the BoNTs, termed A− G, which …
Association of botulinum neurotoxins with synaptic vesicle protein complexes
MR Baldwin, JT Barbieri - Toxicon, 2009 - Elsevier
Botulinum neurotoxins (BoNTs) elicit flaccid paralysis by cleaving SNARE proteins within
peripheral neurons. BoNTs are classified into seven serotypes, termed A–G, based on …
peripheral neurons. BoNTs are classified into seven serotypes, termed A–G, based on …
Botulinum neurotoxin type A is internalized and translocated from small synaptic vesicles at the neuromuscular junction
Botulinum neurotoxin type A (BoNT/A) is the most frequent cause of human botulism and, at
the same time, is largely used in human therapy. Some evidence indicates that it enters …
the same time, is largely used in human therapy. Some evidence indicates that it enters …
Evaluation of the therapeutic usefulness of botulinum neurotoxin B, C1, E, and F compared with the long lasting type A: Basis for distinct durations of inhibition of …
PG Foran, N Mohammed, GO Lisk, S Nagwaney… - Journal of biological …, 2003 - ASBMB
Seven types (A–G) of botulinum neurotoxin (BoNT) target peripheral cholinergic neurons
where they selectively proteolyze SNAP-25 (BoNT/A, BoNT/C1, and BoNT/E), syntaxin1 …
where they selectively proteolyze SNAP-25 (BoNT/A, BoNT/C1, and BoNT/E), syntaxin1 …
Botulinum neurotoxins can enter cultured neurons independent of synaptic vesicle recycling
S Pellett, WH Tepp, JM Scherf, EA Johnson - PLoS One, 2015 - journals.plos.org
Botulinum neurotoxins (BoNTs) are the causative agent of the severe and long-lasting
disease botulism. At least seven different serotypes of BoNTs (denoted AG) have been …
disease botulism. At least seven different serotypes of BoNTs (denoted AG) have been …
Persistence of botulinum neurotoxin A demonstrated by sequential administration of serotypes A and E in rat EDL muscle
M Adler, JE Keller, RE Sheridan, SS Deshpande - Toxicon, 2001 - Elsevier
Botulinum neurotoxin serotypes A (BoNT/A) and E (BoNT/E) inhibit neurotransmitter release
from peripheral cholinergic nerve terminals by cleaving different sites on SNAP-25, a protein …
from peripheral cholinergic nerve terminals by cleaving different sites on SNAP-25, a protein …
Neuronal targeting, internalization, and biological activity of a recombinant atoxic derivative of botulinum neurotoxin A
S Pellett, WH Tepp, LH Stanker, PA Band… - Biochemical and …, 2011 - Elsevier
Non-toxic derivatives of botulinum neurotoxin A (BoNT/A) have potential use as neuron-
targeting delivery vehicles, and as reagents to study intracellular trafficking. We have …
targeting delivery vehicles, and as reagents to study intracellular trafficking. We have …
Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells
M Dong, DA Richards, MC Goodnough… - The Journal of cell …, 2003 - rupress.org
Botulinum neurotoxins (BoNTs) cause botulism by entering neurons and cleaving proteins
that mediate neurotransmitter release; disruption of exocytosis results in paralysis and …
that mediate neurotransmitter release; disruption of exocytosis results in paralysis and …