[HTML][HTML] Unique primed status of microglia under the systemic autoimmune condition of lupus-prone mice
A Nomura, D Noto, G Murayama, A Chiba… - Arthritis Research & …, 2019 - Springer
Background Systemic lupus erythematosus (SLE) is an autoimmune disease characterized
by the production of various autoantibodies. This disease causes disabling neuropsychiatric …
by the production of various autoantibodies. This disease causes disabling neuropsychiatric …
[HTML][HTML] Sustained microglial activation in the area postrema of collagen-induced arthritis mice
T Matsushita, K Otani, Y Oto, Y Takahashi… - Arthritis research & …, 2021 - Springer
Background Central nervous system (CNS)-mediated symptoms, such as fatigue,
depression, and hyperalgesia, are common complications among patients with rheumatoid …
depression, and hyperalgesia, are common complications among patients with rheumatoid …
[HTML][HTML] Interferon-α exacerbates neuropsychiatric phenotypes in lupus-prone mice
J Zeng, X Meng, P Zhou, Z Yin, Q Xie, H Zou… - Arthritis Research & …, 2019 - Springer
Background Neuropsychiatric systemic lupus erythaematosus (NP-SLE) is one of the major
manifestations of lupus. However, the mechanisms involved in NP-SLE are still largely …
manifestations of lupus. However, the mechanisms involved in NP-SLE are still largely …
[HTML][HTML] Regulation of type I interferon signature by VGLL3 in the fibroblast-like synoviocytes of rheumatoid arthritis patients via targeting the Hippo pathway
Y Du, R Cui, N Tian, M Chen, XL Zhang… - Arthritis Research & …, 2022 - Springer
Background The upregulation of interferon (IFN)-stimulated genes induced by type I IFNs
(namely type I IFN signature) in rheumatoid arthritis (RA) patients had implications in early …
(namely type I IFN signature) in rheumatoid arthritis (RA) patients had implications in early …
Inhibitor of NF‐κB kinase subunit ε contributes to neuropsychiatric manifestations in lupus‐prone mice through microglial activation
K Karino, M Kono, S Takeyama, Y Kudo… - Arthritis & …, 2023 - Wiley Online Library
Objective Systemic lupus erythematosus (SLE) is a systemic autoimmune disease
characterized by multiorgan dysfunction. Neuropsychiatric SLE (NPSLE) occurs in 30–40 …
characterized by multiorgan dysfunction. Neuropsychiatric SLE (NPSLE) occurs in 30–40 …
[HTML][HTML] Interleukin-10 attenuation of collagen-induced arthritis is associated with suppression of interleukin-17 and retinoid-related orphan receptor γt production in …
L Ye, Z Wen, Y Li, B Chen, T Yu, L Liu, J Zhang… - Arthritis Research & …, 2014 - Springer
Introduction Our objective in the present study was to determine the signaling pathway of
interleukin 10 (IL-10) for modulating IL-17 expression in macrophages and the importance of …
interleukin 10 (IL-10) for modulating IL-17 expression in macrophages and the importance of …
[HTML][HTML] Mesangial cells of lupus-prone mice are sensitive to chemokine production
SM Ka, CW Cheng, HA Shui, WM Wu… - Arthritis Research & …, 2007 - Springer
Infectious antigens may be triggers for the exacerbation of systemic lupus erythematosus.
The underlying mechanism causing acceleration and exacerbation of lupus nephritis (LN) is …
The underlying mechanism causing acceleration and exacerbation of lupus nephritis (LN) is …
[HTML][HTML] Elevated expression of miR-142-3p is related to the pro-inflammatory function of monocyte-derived dendritic cells in SLE
Y Wang, J Liang, H Qin, Y Ge, J Du, J Lin, X Zhu… - Arthritis research & …, 2016 - Springer
Background Recent studies have shown that alterations in the function of dendritic cells
(DCs) are involved in the pathogenesis of systemic lupus erythematosus (SLE). However …
(DCs) are involved in the pathogenesis of systemic lupus erythematosus (SLE). However …
[HTML][HTML] Dysfunctional interferon-α production by peripheral plasmacytoid dendritic cells upon Toll-like receptor-9 stimulation in patients with systemic lupus …
Background It is well known that interferon (IFN)-α is important to the pathogenesis of
systemic lupus erythematosus (SLE). However, several reports have indicated that the …
systemic lupus erythematosus (SLE). However, several reports have indicated that the …
[HTML][HTML] Association of elevated transcript levels of interferon-inducible chemokines with disease activity and organ damage in systemic lupus erythematosus patients
Q Fu, X Chen, H Cui, Y Guo, J Chen, N Shen… - Arthritis research & …, 2008 - Springer
Introduction Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease
with a heterogeneous course and varying degrees of severity and organ damage; thus …
with a heterogeneous course and varying degrees of severity and organ damage; thus …