Introduction: Proteomic analyses have been acknowledged to carry a significant prospective
in elucidating the pathogenesis of several diseases, including osteoarthritis (OA). But it has …

Osteoarthritis (OA) is characterized by irreversible destruction of the articular cartilage. OA
affects more than 100 million individuals worldwide and has a major impact on patients' …

Understanding biology at the systems level is a powerful method for discovery of previously
unrecognized molecular pathways and mechanisms in human disease. The application of …

Osteoarthritis (OA) is the most frequent rheumatic disease and is the leading cause of
disability in developed countries. Its poorly understood pathophysiology limits the discovery …

Articular cartilage consists of chondrocytes and two major components, a collagen-rich
framework and highly abundant proteoglycans. Most prior studies defining the zonal …

Osteoarthritis (OA) is the most common degenerative joint disorder. OA was conceived as a
“wear and tear” problem of articular cartilage, yet there is a lack of treatment options to delay …

Osteoarthritis is the most common rheumatic pathology and one of the leading causes of
disability worldwide. It is a very complex disease whose etiopathogenesis is not fully …

The progressive nature of osteoarthritis is manifested by the dynamic increase of
degenerated articular cartilage, which is one of the major characteristics of this debilitating …

Osteoarthritis (OA) is a joint degenerative disease that is an exceedingly common problem
associated with aging. Aging is the principal risk factor for OA, but damage-related …

The incidence of age-related musculoskeletal impairment is steadily rising throughout the
world. Musculoskeletal conditions are closely linked with aging and inflammation. They are …