[HTML][HTML] An optimised monophasic faecal extraction method for LC-MS analysis and its application in gastrointestinal disease

PE Kelly, HJ Ng, G Farrell, S McKirdy, RK Russell… - Metabolites, 2022 - mdpi.com
Liquid chromatography coupled with mass spectrometry (LC-MS) metabolomic approaches
are widely used to investigate underlying pathogenesis of gastrointestinal disease and …

Validated high resolution mass spectrometry-based approach for metabolomic fingerprinting of the human gut phenotype

J Vanden Bussche, M Marzorati, D Laukens… - Analytical …, 2015 - ACS Publications
Fecal samples are an obvious choice for metabolomic approaches, since they can be
obtained noninvasively and allow one to study the interactions between the gut microbiota …

Metabolomic analysis—Addressing NMR and LC-MS related problems in human feces sample preparation

S Moosmang, M Pitscheider, S Sturm, C Seger… - Clinica Chimica …, 2019 - Elsevier
Metabolomics is a well-established field in fundamental clinical research with applications in
different human body fluids. However, metabolomic investigations in feces are currently an …

[HTML][HTML] High-throughput UHPLC-MS to screen metabolites in feces for gut metabolic health

A Zawadzki, M Thiele, T Suvitaival, A Wretlind, M Kim… - Metabolites, 2022 - mdpi.com
Feces are the product of our diets and have been linked to diseases of the gut, including
Chron's disease and metabolic diseases such as diabetes. For screening metabolites in …

[HTML][HTML] An LC-QToF MS based method for untargeted metabolomics of human fecal samples

K Cheng, C Brunius, R Fristedt, R Landberg - Metabolomics, 2020 - Springer
Introduction Consensus in sample preparation for untargeted human fecal metabolomics is
lacking. Objectives To obtain sample preparation with broad metabolite coverage for high …

[HTML][HTML] Towards standards for human fecal sample preparation in targeted and untargeted lc-hrms studies

F Hosseinkhani, AC Dubbelman, N Karu, AC Harms… - Metabolites, 2021 - mdpi.com
Gut microbiota and their metabolic products are increasingly being recognized as important
modulators of human health. The fecal metabolome provides a functional readout of the …

Sample preparation optimization in fecal metabolic profiling

O Deda, AC Chatziioannou, S Fasoula… - … of Chromatography B, 2017 - Elsevier
Metabolomic analysis of feces can provide useful insight on the metabolic status, the
health/disease state of the human/animal and the symbiosis with the gut microbiome. As a …

Human Faecal 1H NMR Metabolomics: Evaluation of Solvent and Sample Processing on Coverage and Reproducibility of Signature Metabolites

M Cui, A Trimigno, V Aru, B Khakimov… - Analytical …, 2020 - ACS Publications
The human faecal metabolome is complex, but rich in information and allows investigation of
the host metabolism as a function of diet and health. The faecal metabolome is still much …

[PDF][PDF] Optimisation of sample preparation for direct SPME-GC-MS analysis of murine and human faecal volatile organic compounds for metabolomic studies

S Reade, A Mayor, R Aggio, T Khalid… - J Anal Bioanal …, 2014 - researchgate.net
The analysis of volatile organic compounds (VOCs) emitted from biological fluids such as
blood, urine, breath and faeces, has been receiving more attention from researchers and …

[HTML][HTML] Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn's disease and healthy individuals

JT Bjerrum, Y Wang, F Hao, M Coskun, C Ludwig… - Metabolomics, 2015 - Springer
This study employs spectroscopy-based metabolic profiling of fecal extracts from healthy
subjects and patients with active or inactive ulcerative colitis (UC) and Crohn's disease (CD) …