Whether the cerebral or subcortical lesions are involved in the pathogenesis in infantile
spasms (IS) remains to be determined. To investigate the functional lesions of the …

While infantile spasms is the most common catastrophic epilepsy of infancy and early-
childhood, very little is known about the basic mechanisms responsible for this devastating …

Infantile spasms is an unusual seizure disorder. The seizures themselves are only a few
seconds in duration and consist of brief flexion and/or extension jerking movements. EEG …

The cerebral cortex and thalamus can both generate cyclical oscillations of neuronal activity.
Within the thalamus, sleep spindles are generated as a recurrent interaction between …

Infantile spasms are characterized by age-specific expression of epileptic spasms and
hypsarrhythmia and often result in significant cognitive impairment. Other epilepsies or …

The devastating developmental and epileptic encephalopathy of infantile epileptic spasms
syndrome (IESS) has numerous causes, including, but not limited to, brain injury, metabolic …

Convulsive seizures in animal models usually involve one or more of the following
components:(1) limbic motor seizures,(2) explosive running-bouncing clonic seizures, and …

Infantile spasms are the defining seizures of West syndrome, a severe form of early life
epilepsy with poorly-understood pathophysiology. We present a novel comparative analysis …

The recent intense focus of attention on further characterization and management of infantile
spasms is due, in part, to the resistant nature of these seizures and the frequently poor …

Massive infantile spasms (MIS), a seizure disorder unique to infants, is considered an age-
dependent response of the immature brain to various insults and stressors. The seizures …