From nutritional support to innovative vaccines: Approaches to bolster the immune response to respiratory infection

S Hong - 2024 - search.proquest.com
Respiratory infections pose a significant threat to both human and animal health.
Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract …

Immunogenic potency of engineered exosomes for prevention of respiratory syncytial virus

S Hong, S Ruan, PG Kubota, M He… - The Journal of …, 2020 - journals.aai.org
Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract disease
in infants and young children. Bovine RSV is a common cause of respiratory disease in …

Development of surface engineered antigenic exosomes as vaccines for respiratory syncytial virus

S Hong, S Ruan, Z Greenberg, M He, JL McGill - Scientific Reports, 2021 - nature.com
Respiratory syncytial virus (RSV) is one of the main pathogens associated with lower
respiratory tract infections in infants and young children worldwide. Exosomes secreted by …

Bioengineered small extracellular vesicles used as vaccines deliver multiple SARS-CoV-2 antigenic fragments and drive a broad immunological response

J Edgar - 2024 - repository.cam.ac.uk
The COVID-19 pandemic highlighted the clear risk that zoonotic viruses pose to global
health and economies. The scientific community responded by developing several …

Exosome-mediated antigen delivery: unveiling novel strategies in viral infection control and vaccine design

D El Safadi, A Mokhtari, M Krejbich, A Lagrave… - Vaccines, 2024 - mdpi.com
Exosomes are small subtypes of extracellular vesicles (EVs) naturally released by different
types of cells into their environment. Their physiological roles appear to be multiple, yet …

Exosome-based multivalent vaccine: achieving potent immunization, broadened reactivity, and strong T-cell responses with nanograms of proteins

M Cacciottolo, JB Nice, Y Li, MJ LeClaire… - Microbiology …, 2023 - Am Soc Microbiol
Currently approved vaccines against severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) have focused solely on the spike protein to provide immunity. The first …

Exosomes: the next frontier in vaccine development and delivery

D Tan, G Li, W Fu, C Lei - Frontiers in Immunology, 2024 - frontiersin.org
Exosomes are small disk-shaped extracellular vesicles (EVs) that are naturally released into
the environment by different types of cells. Exosomes range from 30-150 nm in size and …

Multivalent Exosome based protein vaccine: a “mix and match” approach to epidemic viruses' challenges

M Cacciottolo, LE Hsieh, Y Li, MJ LeClaire, JB Nice… - bioRxiv, 2023 - biorxiv.org
Endemic viruses are becoming increasingly the norm, and the development of a rapid and
effective vaccine is emergent. Here, we used our StealthX™ exosome platform to express …

[PDF][PDF] Exosome based multivalent vaccine: achieving potent immunization, broaden reactivity and T cell response with nanograms of proteins without any adjuvant.

M Cacciottolo, JB Nice, Y Li, MJ LeClaire, R Twaddle… - scholar.archive.org
Exosome based vaccines represent an interesting opportunity in the pandemic time we live.
Compared to the available vaccines, an exosome-based vaccine may answer to the need of …

Exosome-based COVID-19 vaccine

J Kim, N Thapa - Cell-Secreted Vesicles: Methods and Protocols, 2023 - Springer
Extracellular vesicles (EVs) enable cell-to-cell communication and, by delivering antigens,
can stimulate the immune response strongly. Approved in use SARS-CoV-2 vaccine …