Many evidences indicate that oxidative stress plays a significant role in a variety of human
disease states, including neurodegenerative diseases. Iron is an essential metal for almost …

Iron (Fe) is an essential element for many metabolic processes, serving as a cofactor for
heme and nonheme proteins. Cellular iron deficiency arrests cell growth and leads to cell …

The accumulation of transition metals (eg, copper, zinc, and iron) and the dysregulation of
their metabolism are a hallmark in the pathogenesis of several neurodegenerative diseases …

Iron is an essential element for life on earth, participating in a plethora of cellular processes
where one-electron transfer reactions are required. Its essentiality, coupled to its scarcity in …

Although iron is essential in maintaining the function of the central nervous system, it is a
potent source of reactive oxygen species. Excessive iron accumulation occurs in many …

Accumulation of iron (Fe) is often detected in the brains of people suffering from
neurodegenerative diseases. High Fe concentrations have been consistently observed in …

The brain shares with other organs the need for a constant and readily available supply of
iron and has a similar array of proteins available to it for iron transport, storage, and …

Enormous advances have been made in the last decade in understanding iron metabolism
and iron homeostasis at both the cellular and the systemic level. This includes the …

Iron is both essential for maintaining a spectrum of metabolic processes in the central
nervous system and elsewhere, and potent source of reactive oxygen species. Redox …

Disturbance of the brain homeostasis, either directly via the formation of abnormal proteins
or cerebral hypo-perfusion, or indirectly via peripheral inflammation, will activate microglia to …