Although gastric cancer (GC) is highly prevalent in China and is a leading cause of cancer-
related death, major advances in early diagnostic and effective therapeutic strategies have …

Background: Transcriptional silencing of tumour suppressor genes by DNA
hypermethylation plays a crucial role in the progression of gastric cancer. Many genes …

Aberrant promoter methylation and subsequent silencing of cancer-related genes has been
recognized as an important pathway involved in gastric carcinogenesis. In fact, several …

In this study, we examined aberrant methylation of the E-cadherin, estrogen receptor, RB1,
p16, p15, p14, and MGMT genes by the methylation-specific polymerase chain reaction …

Promoter hypermethylation is an alternative mechanism of gene silencing in human cancers
including gastric cancer. While intestinal metaplasia (IM) is generally regarded as a …

Genetic changes associated with gastric cancer are not completely known, but epigenetic
mechanisms involved in this disease seem to play an important role in its pathophysiology …

To date, several reports on methylation of various genes in gastric cancer (GC) have been
published. However, most of these studies focused on cancer tissues or a single gene only …

Gastric cancer is one of the most common malignancies and a leading cause of cancer
mortality worldwide. The pathogenesis mechanisms of gastric cancer are still not fully clear …

BACKGROUND Transcriptional silencing by CpG‐island hypermethylation now is believed
to be an important mechanism of tumorigenesis. To date, studies on CpG‐island …

Gastric cancer is one of the most common malignancies and remains the second leading
cause of cancer-related death worldwide. Over 70% of new cases and deaths occur in …