Dynamic N6-methyladenosine RNA methylation in brain and diseases

AM Shafik, EG Allen, P Jin - Epigenomics, 2020 - Taylor & Francis
N6-methyladenosine (m6A) is a dynamic RNA modification that regulates various aspects of
RNA metabolism and has been implicated in many biological processes and transitions …

Epitranscriptomic regulation by m6A RNA methylation in brain development and diseases

AK Chokkalla, SL Mehta… - Journal of Cerebral …, 2020 - journals.sagepub.com
Cellular RNAs are pervasively tagged with diverse chemical moieties, collectively called
epitranscriptomic modifications. The methylation of adenosine at N6 position generates N6 …

The epigenetics of aging and neurodegeneration

R Lardenoije, A Iatrou, G Kenis, K Kompotis… - Progress in …, 2015 - Elsevier
Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

N6-Methyladenosines modulate A-to-I RNA editing

JF Xiang, Q Yang, CX Liu, M Wu, LL Chen, L Yang - Molecular cell, 2018 - cell.com
Summary N 6-methyladenosine (m 6 A) and adenosine-to-inosine (A-to-I) editing are two of
the most abundant RNA modifications, both at adenosines. Yet, the interaction of these two …

RNA editing—systemic relevance and clue to disease mechanisms?

JC Meier, S Kankowski, H Krestel… - Frontiers in molecular …, 2016 - frontiersin.org
Recent advances in sequencing technologies led to the identification of a plethora of
different genes and several hundreds of amino acid recoding edited positions. Changes in …

The effects of N6-methyladenosine RNA methylation on the nervous system

N Shao, T Ye, W Xuan, M Zhang, Q Chen, J Liu… - Molecular and Cellular …, 2023 - Springer
Epitranscriptomics, also known as “RNA epigenetics”, is a type of chemical modification that
regulates RNA. RNA methylation is a significant discovery after DNA and histone …

Evolutionary and ontogenetic changes in RNA editing in human, chimpanzee, and macaque brains

Z Li, H Bammann, M Li, H Liang, Z Yan, YPP Chen… - Rna, 2013 - rnajournal.cshlp.org
Adenosine-to-inosine (A-to-I) substitutions are the most common type of RNA editing in
mammals. A-to-I RNA editing is particularly widespread in the brain and is known to play …

Alternative splicing in neurodegenerative disease and the promise of RNA therapies

D Nikom, S Zheng - Nature Reviews Neuroscience, 2023 - nature.com
Alternative splicing generates a myriad of RNA products and protein isoforms of different
functions from a single gene. Dysregulated alternative splicing has emerged as a new …

[HTML][HTML] N6-methyladenosine (m6A) modification and its clinical relevance in cognitive dysfunctions

B Du, Y Zhang, M Liang, Z Du, H Li, C Fan… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Background: N6 adenosine methylation (m6A) is the most abundant internal RNA
modification in eukaryotic cells. Dysregulation of m6A has been associated with the …

[HTML][HTML] Spatiotemporal and genetic regulation of A-to-I editing throughout human brain development

WH Cuddleston, X Fan, L Sloofman, L Liang… - Cell reports, 2022 - cell.com
Posttranscriptional RNA modifications by adenosine-to-inosine (A-to-I) editing are abundant
in the brain, yet elucidating functional sites remains challenging. To bridge this gap, we …