Endogenous opioid system in addiction and addiction-related behaviors
B Reed, ER Butelman, MJ Kreek - Current opinion in behavioral sciences, 2017 - Elsevier
Highlights•Alterations in endogenous opioid system components occur in development of
addiction.•Human studies and animal models show opioid genes contribute to addiction …
addiction.•Human studies and animal models show opioid genes contribute to addiction …
Opioid receptor and peptide gene polymorphisms: potential implications for addictions
KS LaForge, V Yuferov, MJ Kreek - European journal of pharmacology, 2000 - Elsevier
Addictions to drugs of abuse and alcohol have been shown by studies of genetic
epidemiology to have both a heritable and an environmental basis, with these factors …
epidemiology to have both a heritable and an environmental basis, with these factors …
The genetics of the opioid system and specific drug addictions
O Levran, V Yuferov, MJ Kreek - Human genetics, 2012 - Springer
Addiction to drugs is a chronic, relapsing brain disease that has major medical, social, and
economic complications. It has been established that genetic factors contribute to the …
economic complications. It has been established that genetic factors contribute to the …
Molecular mechanisms of opioid dependence by using knockout mice
BL Kieffer, F Simonin - Molecular biology of drug addiction, 2003 - Springer
Opium, extracted from the seed of the poppy Papaver somniferum, has been used and
abused for several thousand years. This substance is highly efficient to relieve pain or treat …
abused for several thousand years. This substance is highly efficient to relieve pain or treat …
The neurobiology of addiction: where we have been and where we are going
GF Koob, EJ Simon - Journal of drug issues, 2009 - journals.sagepub.com
A number of dramatic breakthroughs in the neurobiology of addiction have occurred in the
past 40 years. Two domains will be highlighted: the neurocircuitry of addiction and the …
past 40 years. Two domains will be highlighted: the neurocircuitry of addiction and the …
Modulation of alcohol and nicotine responses through the endogenous opioid system
E Drews, A Zimmer - Progress in neurobiology, 2010 - Elsevier
It has been estimated that more than 80% of alcoholics are also nicotine dependent and
that, vice versa, the rate of alcoholism is substantially increased by a factor of 4–10 in the …
that, vice versa, the rate of alcoholism is substantially increased by a factor of 4–10 in the …
15 years of genetic approaches in vivo for addiction research: Opioid receptor and peptide gene knockout in mouse models of drug abuse
P Charbogne, BL Kieffer, K Befort - Neuropharmacology, 2014 - Elsevier
The endogenous opioid system is expressed throughout the brain reinforcement circuitry,
and plays a major role in reward processing, mood control and the development of …
and plays a major role in reward processing, mood control and the development of …
The endogenous opioid system: a common substrate in drug addiction
Drug addiction is a chronic brain disorder leading to complex adaptive changes within the
brain reward circuits that involve several neurotransmitters. One of the neurochemical …
brain reward circuits that involve several neurotransmitters. One of the neurochemical …
Endogenous opioids at the intersection of opioid addiction, pain, and depression: the search for a precision medicine approach
Opioid addiction and overdose are at record levels in the United States. This is driven, in
part, by their widespread prescription for the treatment of pain, which also increased …
part, by their widespread prescription for the treatment of pain, which also increased …
[PDF][PDF] Endogenous opioids: overview and current issues
H Akil, C Owens, H Gutstein, L Taylor, E Curran… - Drug Alcohol …, 1998 - academia.edu
It is now well established that opiate drugs, such as heroin and morphine exert their primary
effects by mimicking naturally occurring substances, termed the opioid peptides or …
effects by mimicking naturally occurring substances, termed the opioid peptides or …