Tumor-infiltrating lymphocytes: clinical experience

MJ Besser, R Shapira-Frommer… - The Cancer Journal, 2015 - journals.lww.com
Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) in combination with
lymphodepletion and high-dose interleukin 2 has shown reproducible objective response …

White paper on adoptive cell therapy for cancer with tumor-infiltrating lymphocytes: a report of the CTEP subcommittee on adoptive cell therapy

J Weber, M Atkins, P Hwu, L Radvanyi, M Sznol… - Clinical Cancer …, 2011 - AACR
Adoptive T-cell therapy (ACT) using expanded autologous tumor-infiltrating lymphocytes
(TIL) and tumor antigen-specific T cell expanded from peripheral blood are complex but …

Adoptive transfer of tumor-infiltrating lymphocytes in melanoma: a viable treatment option

MW Rohaan, JH van den Berg, P Kvistborg… - … for immunotherapy of …, 2018 - Springer
The treatment of metastatic melanoma patients with autologous tumor-infiltrating
lymphocytes (TIL) shows robust, reproducible, clinical responses in clinical trials executed in …

Tumor-infiltrating lymphocyte therapy in melanoma: facts to the future

A Betof Warner, PG Corrie, O Hamid - Clinical Cancer Research, 2023 - AACR
Adoptive cell therapy with tumor-infiltrating lymphocytes (TIL) is gaining momentum and
demonstrating durable responses in patients with advanced melanoma. Although …

Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients

LG Radvanyi, C Bernatchez, M Zhang, PS Fox… - Clinical Cancer …, 2012 - AACR
Purpose: Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) is
a promising treatment for metastatic melanoma unresponsive to conventional therapies. We …

[HTML][HTML] Tumor-infiltrating lymphocytes for the treatment of metastatic cancer

MHG Foppen, M Donia, IM Svane, J Haanen - Molecular oncology, 2015 - Elsevier
Over the past few years melanoma incidence has been rising steadily, resulting in an
increase in melanoma related mortality. Until recently, therapeutic options for metastatic …

Advances in the development of tumor-infiltrating lymphocyte therapy for advanced melanoma

M Julve, AJS Furness - Expert Opinion on Biological Therapy, 2023 - Taylor & Francis
The use of autologous tumor-infiltrating lymphocytes (TILs) as an advanced cancer therapy
has been well documented since the late 1980s. Despite steady progress in the field, it …

Achievements and challenges of adoptive T cell therapy with tumor-infiltrating or blood-derived lymphocytes for metastatic melanoma: what is needed to achieve …

IM Svane, EM Verdegaal - Cancer immunology, immunotherapy, 2014 - Springer
Adoptive cell therapy (ACT) based on autologous T cell derived either from tumor as tumor-
infiltrating lymphocytes (TILs) or from peripheral blood is developing as a key area of future …

Phase II clinical trial of adoptive cell therapy for patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and low-dose interleukin-2

LT Nguyen, SD Saibil, V Sotov, MX Le, L Khoja… - Cancer Immunology …, 2019 - Springer
Adoptive cell therapy using autologous tumor-infiltrating lymphocytes (TIL) has shown
significant clinical benefit, but is limited by toxicities due to a requirement for post-infusion …

[HTML][HTML] Biomarkers for response to TIL therapy: a comprehensive review

VA Fernández, PB Martínez, JS Granhøj… - … for Immunotherapy of …, 2024 - ncbi.nlm.nih.gov
Adoptive cell therapy with tumor-infiltrating lymphocytes (TIL) has demonstrated durable
clinical responses in patients with metastatic melanoma, substantiated by recent positive …