Colorectal cancer (CRC) is the second-deadliest cancer in the world, yet a deeper
understanding of spatial patterns of gene expression in the tumor microenvironment (TME) …

Determining the diverse cell types in the tumor microenvironment (TME) and their
organization into cellular communities, is critical for understanding the biological …

Colorectal cancer (CRC) is among the most common malignancies with limited treatments
other than surgery. The tumor microenvironment (TME) profiling enables the discovery of …

The current challenge in analyzing sequencing-based spatial transcriptomics (ST) is to
precisely resolve the spatial distribution of cell subpopulations with low abundance and …

Background Understanding the tumor microenvironment (TIME) requires more than just a
catalog of cell types and gene programs. It is critical to see the spatial organization of the …

The tumor microenvironment is a complex ecosystem formed by distinct and interacting cell
populations, and its composition is related to cancer prognosis and response to clinical …

Antitumoral immunity requires organized, spatially nuanced interactions between
components of the immune tumor microenvironment (iTME). Understanding this coordinated …

Profiling heterologous cell types within tumors is essential to decipher tumor
microenvironment that shapes tumor progress and determines the outcome of therapeutic …

The cellular interactions in the tumor microenvironment of colorectal cancer (CRC) are
poorly understood, hindering patient treatment. In the current study, we investigate whether …

While advances in single cell genomics have helped to chart the cellular components of
tumor ecosystems, it has been more challenging to characterize their specific spatial …