In order to expand structural diversity and improve antitumor efficiency, forty new
naphthoquinone phenacylimidazolium derivatives were designed, synthesized and …

Hit, Lead & Candidate Discovery It is reported that 1, 4‐naphthoquinones and their
derivatives have potent antitumor activity in various cancers, although their clinical …

A series of new bisbenzylisoquinoline alkaloids was partially synthesized from tetrandrine
and fangchinoline and evaluated for their ability to reverse P-glycoprotein-mediated …

Overexpression of P-glycoprotein (P-gp) plays a key role in the development of multidrug
resistance (MDR), the major reason for the failure of chemotherapy in clinics. Ocotillol and its …

Aim: To investigate the ability of synthetic benzo [a] quinolizin-4-one derivatives to reverse
multidrug resistance (MDR) in lung cancer cells. Materials and Methods: A cell line with …

Introduction Malignacies are still a major public concern worldwide and despite the intensive
search of new chemotherapeutic agents, treatment still remains a challenging issue. The …

The search for novel anticancer drugs is essential to expand treatment options, overcome
drug resistance, reduce toxicity, promote innovation, and tackle the economic impact. The …

A series of 2-substituted amino-3-chloro-1, 4-naphthoquinone derivatives (3–12) were
synthesized as anticancer agents and tested against four cancer cell lines including HepG2 …

Multidrug resistance (MDR) is a major cause of failure in cancer treatment, in which the
overexpression of P-glycoprotein (Pgp) plays a crucial role. Herein, a novel class of ocotillol …

Naphthoquinones (1, 4-NQ) have been reported to possess a variety of pharma-cological
properties including antibacterial, antifungal, antiviral, anti-inflammatory, anti …