Design, synthesis and anticancer activity of naphthoquinone derivatives
X Shen, Y Wang, X Han, L Sheng, F Wu… - Journal of Enzyme …, 2020 - Taylor & Francis
Basis on molecular docking and pharmacophore analysis of naphthoquinone moiety, a total
of 23 compounds were designed and synthesised. With the help of reverse targets …
of 23 compounds were designed and synthesised. With the help of reverse targets …
[HTML][HTML] The antiproliferative and apoptotic effects of a novel quinazoline carrying substituted-sulfonamides: In vitro and molecular docking study
In order to investigate for a new effective and safe anticancer drug, we synthesized a novel
series of quinazoline containing biologically active substituted-sulfonamide moiety at 3 …
series of quinazoline containing biologically active substituted-sulfonamide moiety at 3 …
Novel 1, 4-naphthoquinone-based sulfonamides: Synthesis, QSAR, anticancer and antimalarial studies
R Pingaew, V Prachayasittikul… - European Journal of …, 2015 - Elsevier
Abstract A novel series of 1, 4-naphthoquinones (33–44) tethered by open and closed chain
sulfonamide moieties were designed, synthesized and evaluated for their cytotoxic and …
sulfonamide moieties were designed, synthesized and evaluated for their cytotoxic and …
Synthesis and primary evaluation of quinoxalinone derivatives as potent modulators of multidrug resistance
H Yuan, X Li, X Qu, L Sun, W Xu, W Tang - Medicinal chemistry research, 2009 - Springer
P-glycoprotein-mediated drug efflux from cells is believed to be an important mechanism in
multidrug resistance (MDR) in cancer chemotherapy. The identification and development of …
multidrug resistance (MDR) in cancer chemotherapy. The identification and development of …
Morpholine substituted quinazoline derivatives as anticancer agents against MCF-7, A549 and SHSY-5Y cancer cell lines and mechanistic studies
A series of morpholine substituted quinazoline derivatives have been synthesized and
evaluated for cytotoxic potential against A549, MCF-7 and SHSY-5Y cancer cell lines. These …
evaluated for cytotoxic potential against A549, MCF-7 and SHSY-5Y cancer cell lines. These …
Design, synthesis, and biological evaluation of chalcone oxime derivatives as potential immunosuppressive agents
A series of deoxybenzoin oximes were recently reported as potent immunosuppressive
agents by our group. In order to continue the original research for potential …
agents by our group. In order to continue the original research for potential …
[HTML][HTML] Synthesis, antitumor activity and docking of 2, 3-(substituted)-1, 4-naphthoquinone derivatives containing nitrogen, oxygen and sulfur
M Delarmelina, RD Daltoé, MF Cerri… - Journal of the Brazilian …, 2015 - SciELO Brasil
Eleven 2, 3-(substituted)-1, 4-naphthoquinone derivatives were synthesized in yields
ranging from 52-89%. These derivatives were evaluated for their cytotoxic effects on human …
ranging from 52-89%. These derivatives were evaluated for their cytotoxic effects on human …
Structure–activity relationships of 8-hydroxyquinoline-derived Mannich bases with tertiary amines targeting multidrug-resistant cancer
A recently proposed strategy to overcome multidrug resistance (MDR) in cancer is to target
the collateral sensitivity of otherwise resistant cells. We designed a library of 120 …
the collateral sensitivity of otherwise resistant cells. We designed a library of 120 …
[HTML][HTML] Activity of new synthetic (2-chloroethylthio)-1, 4-naphthoquinones in prostate cancer cells
SA Dyshlovoy, DN Pelageev, LS Jakob, KL Borisova… - Pharmaceuticals, 2021 - mdpi.com
Development of resistance to currently available standard therapies in advanced prostate
cancer (PCa) emphasizes the need for novel therapeutic options. Here, we report the …
cancer (PCa) emphasizes the need for novel therapeutic options. Here, we report the …