Multidrug resistance (MDR) limits the therapeutic effect of conventional chemotherapeutic
agents as well as novel targeted anticancer drugs. An important mechanism of MDR is the …

All of 13 (E)-6-(1-alkyloxyiminomethyl)-5, 8-dimethoxy-1, 4-naphthoquinone derivatives
synthesized showed high ED50 values, ranging from 0.1 to 0.3 μg/mL against L1210 cells …

Abstract Derivatives of 1, 4‑naphthoquinone have excellent anti‑cancer effects, but their use
has been greatly limited due to their serious side effects. To develop compounds with …

ABSTRACT A series of 3-aryl/hetarylquinoxaline-2-carbonitrile-1, 4-dioxides was
synthesized and evaluated against breast cancer cell lines in normoxia and hypoxia …

A series of methyl 2-[3-(3-phenyl-quinoxalin-2-ylsulfanyl) propanamido] alkanoates and their
corresponding hydrazides and N-alkyl 3-((3-phenylquinoxalin-2-yl) sulfanyl) propanamides …

Quinones are plant-derived secondary metabolites that present diverse pharmacological
properties, including antibacterial, antifungal, antiviral, anti-inflammatory, antipyretic and …

Background: Cancer treatment often fails due to multidrug resistance (MDR) of the tumor
cells. One of the major causes is overexpression of P-glycoprotein (P-gp). Materials and …

We report a study of a series of isoquinoline derivatives, including their synthesis, in vitro
microsomal leucine aminopeptidase (LAP) inhibition and antiproliferative activity on cancer …

A robust economic approach to N-(quinazoline-4-yl) sulfonamides was developed and
synthesized different aryl, hetero aryl, alkyl and cyclopropyl sulfonamides in excellent yields …

P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is a principal obstacle for
successful cancer chemotherapy. A novel P-gp inhibitor with a quinazoline scaffold, 12k …