During past decades, twin studies have played an important role in genetic epidemiology
studies of complex traits. The strength of twin studies lies in the ability to disentangle genetic …

The regulation of gene expression plays a pivotal role in complex phenotypes, and
epigenetic mechanisms such as DNA methylation are essential to this process. The …

Twin studies have been a valuable source of information about the genetic basis of complex
traits. To maximize the potential of twin studies, large, worldwide registers of data on twins …

Although cells of an individual generally all have the same DNA, each cell type has a unique
pattern of active (expressed) and inactive genes. These patterns are established or …

In this issue of Twin Research, we describe different facets of a European Community
funded effort, GenomEUtwin, which capitalises on eight of the world's largest and best …

Twin studies have had a key role in the evaluation of heritability, a population-based
estimate of the genetic contribution to phenotypic variation. These studies have led to the …

The challenge faced by research into the genetic basis of complex disease is to identify
genes of small relative effect against a background of substantial genetic and environmental …

Monozygotic (MZ) twins share nearly all of their genetic variants and many similar
environments before and after birth. However, they can also show phenotypic discordance …

The University of Washington Twin Registry is a unique community-based registry of twin
pairs who join specifically to participate in scientific research. It was founded in 2002 to …

In 1984, Hrubec and Robinette published what was arguably the first review of the role of
twins in medical research. The authors acknowledged a growing distinction between two …