Pregnancy is a complex state where changes in maternal physiology have evolved to favor
the development and growth of the placenta and the fetus. These adaptations may affect …

Pharmacokinetics describes the handling of a drug by the body–how the drug is absorbed,
distributed and eliminated and how these processes determine plasma concentrations of the …

Significant changes in the physiological and biotransformation processes that govern
pharmacokinetics occur during pregnancy. Consequently, the disposition of many …

Pharmacologic interventions play a major role in obstetrical care throughout pregnancy,
labor and delivery and the postpartum. Traditionally, obstetrical providers have utilized …

The extensive metabolic demands of pregnancy require specific physiological and
anatomical changes. These changes affect almost all organ systems, including the …

Physiologic changes in pregnancy induce profound alterations to the pharmacokinetic
properties of many medications. These changes affect distribution, absorption, metabolism …

Objective: To review the literature regarding how drug pharmacokinetics differ between
pregnant and nongravid women. Data Sources: Articles published between 1963 and 1997 …

Purpose To critically review pregnancy-induced pharmacokinetic changes and their clinical
application. Methods Structured review of Pubmed, MBASE and published books. Results …

Observational studies have documented that women take a variety of medications during
pregnancy. It is well known that pregnancy can induce changes in the plasma …

Any drug given to a pregnant woman must be considered as possibly harmful to the fetus,
since all drugs administered to the mother cross the placental membrane, although at …