Cutting edge: regulation of intestinal inflammation and barrier function by IL-17C
JM Reynolds, GJ Martinez, KC Nallaparaju… - The Journal of …, 2012 - journals.aai.org
In the IL-17 family of cytokines, much is known about the sources and functions of IL-17, IL-
17F, and IL-25 in the host defense against infection and in inflammatory diseases; however …
17F, and IL-25 in the host defense against infection and in inflammatory diseases; however …
[HTML][HTML] Interleukin-23-independent IL-17 production regulates intestinal epithelial permeability
Summary Whether interleukin-17A (IL-17A) has pathogenic and/or protective roles in the gut
mucosa is controversial and few studies have analyzed specific cell populations for …
mucosa is controversial and few studies have analyzed specific cell populations for …
A protective function for interleukin 17A in T cell–mediated intestinal inflammation
W O'Connor Jr, M Kamanaka, CJ Booth, T Town… - Nature …, 2009 - nature.com
Abstract Interleukin 23 (IL-23) and IL-17 have been linked to the pathogenesis of several
chronic inflammatory disorders, including inflammatory bowel disease. Yet as an important …
chronic inflammatory disorders, including inflammatory bowel disease. Yet as an important …
[HTML][HTML] The development of colitis in Il10−/− mice is dependent on IL-22
DC Gunasekera, J Ma, V Vacharathit, P Shah… - Mucosal …, 2020 - Elsevier
Mice deficient in the IL-10 pathway are the most widely used models of intestinal
immunopathology. IL-17A is strongly implicated in gut disease in mice and humans, but …
immunopathology. IL-17A is strongly implicated in gut disease in mice and humans, but …
Neutralizing IL-23 is superior to blocking IL-17 in suppressing intestinal inflammation in a spontaneous murine colitis model
Background IL-23/TH17 inflammatory responses are regarded as central to the
pathogenesis of inflammatory bowel disease, but clinically IL-17A antibodies have shown …
pathogenesis of inflammatory bowel disease, but clinically IL-17A antibodies have shown …
IL-17C regulates the innate immune function of epithelial cells in an autocrine manner
V Ramirez-Carrozzi, A Sambandam, E Luis, Z Lin… - Nature …, 2011 - nature.com
Abstract Interleukin 17C (IL-17C) is a member of the IL-17 family that is selectively induced
in epithelia by bacterial challenge and inflammatory stimuli. Here we show that IL-17C …
in epithelia by bacterial challenge and inflammatory stimuli. Here we show that IL-17C …
[HTML][HTML] Regulation of inflammatory responses by IL-17F
Although interleukin (IL) 17 has been extensively characterized, the function of IL-17F, which
has an expression pattern regulated similarly to IL-17, is poorly understood. We show that …
has an expression pattern regulated similarly to IL-17, is poorly understood. We show that …
[HTML][HTML] Interleukin-17 induces an atypical M2-like macrophage subpopulation that regulates intestinal inflammation
K Nishikawa, N Seo, M Torii, N Ma, D Muraoka… - PloS one, 2014 - journals.plos.org
Interleukin 17 (IL-17) is a pleiotropic cytokine that acts on both immune and non-immune
cells and is generally implicated in inflammatory and autoimmune diseases. Although IL-17 …
cells and is generally implicated in inflammatory and autoimmune diseases. Although IL-17 …
Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota
C Tang, S Kakuta, K Shimizu, M Kadoki, T Kamiya… - Nature …, 2018 - nature.com
The cytokines IL-17A and IL-17F have 50% amino-acid identity and bind the same receptor;
however, their functional differences have remained obscure. Here we found that Il17f …
however, their functional differences have remained obscure. Here we found that Il17f …
IL-22–producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis
CL Zindl, JF Lai, YK Lee, CL Maynard… - Proceedings of the …, 2013 - National Acad Sciences
IL-22 plays an important role in mucosal epithelial cell homeostasis. Using a dextran sodium
sulfate-induced mouse model of acute colitis, we observed an IL-23–dependent up …
sulfate-induced mouse model of acute colitis, we observed an IL-23–dependent up …