In the IL-17 family of cytokines, much is known about the sources and functions of IL-17, IL-
17F, and IL-25 in the host defense against infection and in inflammatory diseases; however …

Summary Whether interleukin-17A (IL-17A) has pathogenic and/or protective roles in the gut
mucosa is controversial and few studies have analyzed specific cell populations for …

Abstract Interleukin 23 (IL-23) and IL-17 have been linked to the pathogenesis of several
chronic inflammatory disorders, including inflammatory bowel disease. Yet as an important …

Mice deficient in the IL-10 pathway are the most widely used models of intestinal
immunopathology. IL-17A is strongly implicated in gut disease in mice and humans, but …

Background IL-23/TH17 inflammatory responses are regarded as central to the
pathogenesis of inflammatory bowel disease, but clinically IL-17A antibodies have shown …

Abstract Interleukin 17C (IL-17C) is a member of the IL-17 family that is selectively induced
in epithelia by bacterial challenge and inflammatory stimuli. Here we show that IL-17C …

Although interleukin (IL) 17 has been extensively characterized, the function of IL-17F, which
has an expression pattern regulated similarly to IL-17, is poorly understood. We show that …

Interleukin 17 (IL-17) is a pleiotropic cytokine that acts on both immune and non-immune
cells and is generally implicated in inflammatory and autoimmune diseases. Although IL-17 …

The cytokines IL-17A and IL-17F have 50% amino-acid identity and bind the same receptor;
however, their functional differences have remained obscure. Here we found that Il17f …

IL-22 plays an important role in mucosal epithelial cell homeostasis. Using a dextran sodium
sulfate-induced mouse model of acute colitis, we observed an IL-23–dependent up …