Nuclear localization of Y-box factor YB1 requires wild-type p53

YF Zhang, C Homer, SJ Edwards, L Hananeia… - Oncogene, 2003 - nature.com
Nuclear localization and high levels of the Y-box binding protein YB1 appear to be important
indicators of drug resistance and tumor prognosis. YB1 also interacts with the p53 tumor …

Y-box-binding protein 1 confers EGF independence to human mammary epithelial cells

IM Berquin, B Pang, ML Dziubinski, LM Scott, YQ Chen… - Oncogene, 2005 - nature.com
The epidermal growth factor receptor (EGFR) is linked to poor outcome in breast cancer, and
resistance to hormonal therapy is often accompanied by activation of growth factor …

Strong YB‐1 expression is associated with liver metastasis progression and predicts shorter disease‐free survival in advanced gastric cancer

Y Wu, S Yamada, H Izumi, Z Li… - Journal of surgical …, 2012 - Wiley Online Library
Background The most significant cause of gastric cancer (GC) death is metastasis, although
the underlying mechanisms remain obscure. Y‐box binding protein‐1 (YB‐1) is associated …

Phosphorylation by Akt disables the anti-oncogenic activity of YB-1

AG Bader, PK Vogt - Oncogene, 2008 - nature.com
The Y box-binding protein 1 (YB-1) is a DNA/RNA-binding protein that regulates mRNA
transcription and translation. It is a major component of free messenger ribonucleoprotein …

The feed-forward loop between YB-1 and MYC is essential for multiple myeloma cell survival

KS Bommert, M Effenberger, E Leich, M Küspert… - Leukemia, 2013 - nature.com
Y-box binding protein 1 (YB-1) functions as a translational regulator and has been
suggested to elevate MYC mRNA translation via an internal ribosome entry segment (IRES) …

Upregulated YB-1 protein promotes glioblastoma growth through a YB-1/CCT4/mLST8/mTOR pathway

JZ Wang, H Zhu, P You, H Liu… - The Journal of …, 2022 - Am Soc Clin Investig
Y-box–binding protein 1 (YB-1) is a multifunctional RNA binding protein involved in virtually
every step of RNA metabolism. However, the functions and mechanisms of YB-1 in one of …

Y box binding protein 1 (YB-1) oncoprotein at the hub of DNA proliferation, damage and cancer progression

F Sangermano, A Delicato, V Calabrò - Biochimie, 2020 - Elsevier
The Y Box binding protein 1 (YB-1) belongs to the highly conserved Cold Shock Domain
protein family and is a major component of messenger ribonucleoprotein particles (mRNPs) …

Genotoxic stress-induced nuclear localization of oncoprotein YB-1 in the absence of proteolytic processing

SB Cohen, W Ma, VA Valova, M Algie, R Harfoot… - Oncogene, 2010 - nature.com
Abstract Y-box-binding protein 1 (YB-1) is an oncogenic transcription factor whose
overexpression and nuclear localization is associated with tumor progression and drug …

Y box binding protein 1 inhibition as a targeted therapy for ovarian cancer

D Tailor, A Resendez, FJ Garcia-Marques… - Cell Chemical …, 2021 - cell.com
Y box binding protein 1 (YB-1) is a multifunctional protein associated with tumor progression
and the emergence of treatment resistance (TR). Here, we report an azopodophyllotoxin …

YB1 regulates miR‐205/200b‐ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma

X Liu, D Chen, H Chen, W Wang, Y Liu… - Cancer …, 2021 - Wiley Online Library
Background Y‐box binding protein 1 (YB1 or YBX1) plays a critical role in tumorigenesis
and cancer progression. However, whether YB1 affects malignant transformation by …