Background: The first part of this two-part review discussed approaches to generating
antagonists for some of the CC chemokine receptors, including CCR1, CCR2, CCR3, and …

Background: Chemokines were originally defined as host defense proteins, however, their
biological role goes well beyond this simple description of their function as immune cell …

Chemokine receptors have a key role in the pathogenesis of autoimmune diseases,
inflammation and viral infection. However, with the exception of selective CCR5 antagonists …

The selective accumulation and activation of leukocytes in inflamed tissues contributes to
the pathogenesis of inflammatory and autoimmune diseases such as infection, rheumatoid …

Human immunodeficiency virus (HIV) infection with its clinical progression to AIDS has
become one of the fatal diseases in the world and the leading cause of death in Africa. 1 …

The identification of chemokines and their receptors as potent mediators of leukocyte
infiltration raised interest in the potential role of these proteins on disease pathogenesis …

Chemokines are small basic proteins that are defined by the number and position of the
invariant cysteines in their protein sequence. 1 At the time this review was written more than …

The CCR5 chemokine receptor is expressed on a wide range of immune cell types and
binding to this receptor mediates cellular entry by the majority of HIV isolates. Blocking viral …

Chemokine receptors belong to one of the most pharmacologically exploited proteins, the G-
protein-coupled receptors. Drugs that target these receptors make up greater than 45% of all …

Recent Progress in the Discovery of New CCR5 and CXCR4 Chemokine Receptor
Antagonists as Inhibitors of HIV-1 Entry. Part 2* Page 1 Curr. Med. Chem. - Anti-Infective …