Lithium augmentation of ketamine increases insulin signaling and antidepressant-like active stress coping in a rodent model of treatment-resistant depression
JB Price, CG Yates, BA Morath… - Translational …, 2021 - nature.com
Lithium, a mood stabilizer and common adjunctive treatment for refractory depression,
shares overlapping mechanisms of action with ketamine and enhances the duration of …
shares overlapping mechanisms of action with ketamine and enhances the duration of …
Ketamine for depression: an update
JW Murrough - Biological Psychiatry, 2016 - biologicalpsychiatryjournal.com
A decade has now passed since research into the antidepressant effects of ketamine began
in earnest, after the clinical trial reported by Zarate et al. in 2006 (1). In that proof-of-concept …
in earnest, after the clinical trial reported by Zarate et al. in 2006 (1). In that proof-of-concept …
Calcium/calmodulin-dependent protein kinase II and eukaryotic elongation factor 2 kinase pathways mediate the antidepressant action of ketamine
C Adaikkan, E Taha, I Barrera, O David… - Biological psychiatry, 2018 - Elsevier
Background Ketamine is an N-methyl-D-aspartate receptor antagonist, which on
administration produces fast-acting antidepressant responses in patients with major …
administration produces fast-acting antidepressant responses in patients with major …
Ketamine induces rapid and sustained antidepressant-like effects in chronic pain induced depression: Role of MAPK signaling pathway
Chronic pain produces psychologic distress, which often leads to mood disorders such as
depression. Co-existing chronic pain and depression pose a serious socio-economic …
depression. Co-existing chronic pain and depression pose a serious socio-economic …
[HTML][HTML] Sex-Specific Alterations in Spatial Memory and Hippocampal AKT-mTOR Signaling in Adult Mice Pre-exposed to Ketamine and/or Psychological Stress …
Background Ketamine (KET) is administered to manage major depression in adolescent
patients. However, the long-term effects of juvenile KET exposure on memory-related tasks …
patients. However, the long-term effects of juvenile KET exposure on memory-related tasks …
Ketamine‐induced inhibition of glycogen synthase kinase‐3 contributes to the augmentation of α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic acid (AMPA) …
Objectives Sub‐anesthetic doses of ketamine have been found to provide rapid
antidepressant actions, indicating that the cellular signaling systems targeted by ketamine …
antidepressant actions, indicating that the cellular signaling systems targeted by ketamine …
The mechanisms behind rapid antidepressant effects of ketamine: a systematic review with a focus on molecular neuroplasticity
The mechanism of action underlying ketamine's rapid antidepressant effects in patients with
depression, both suffering from major depressive disorder (MDD) and bipolar disorder (BD) …
depression, both suffering from major depressive disorder (MDD) and bipolar disorder (BD) …
The extracellular signal-regulated kinase pathway contributes to the control of behavioral excitement
The extracellular signal-regulated kinase (ERK) pathway mediates neuronal plasticity in the
CNS. The mood stabilizers lithium and valproate activate the ERK pathway in prefrontal …
CNS. The mood stabilizers lithium and valproate activate the ERK pathway in prefrontal …
Ketamine ameliorates depressive-like behaviors in mice through increasing glucose uptake regulated by the ERK/GLUT3 signaling pathway
X Ouyang, Z Wang, M Luo, M Wang, X Liu, J Chen… - Scientific Reports, 2021 - nature.com
To investigate the effects of ketamine on glucose uptake and glucose transporter (GLUT)
expression in depressive-like mice. After HA1800 cells were treated with ketamine, 2-[N-(7 …
expression in depressive-like mice. After HA1800 cells were treated with ketamine, 2-[N-(7 …
Ketamine's Amelioration of Fear Extinction in Adolescent Male Mice Is Associated with the Activation of the Hippocampal Akt-mTOR-GluA1 Pathway
Fear-related disorders, including post-traumatic stress disorder (PTSD), and anxiety
disorders are pervasive psychiatric conditions marked by persistent fear, stemming from its …
disorders are pervasive psychiatric conditions marked by persistent fear, stemming from its …