[HTML][HTML] Ketamine: translating mechanistic discoveries into the next generation of glutamate modulators for mood disorders
CA Zarate, R Machado-Vieira - Molecular psychiatry, 2017 - nature.com
Over the last decade, numerous controlled studies have consistently described rapid, robust,
and relatively sustained antidepressant response rates associated with single-dose …
and relatively sustained antidepressant response rates associated with single-dose …
[HTML][HTML] R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects
Although the efficacy of racemate ketamine, a rapid onset and sustained antidepressant, for
patients with treatment-resistant depression was a serendipitous finding, clinical use of …
patients with treatment-resistant depression was a serendipitous finding, clinical use of …
Astrocyte activation, but not microglia, is associated with the experimental mouse model of schizophrenia induced by chronic ketamine
Y Wei, L Xiao, W Fan, J Zou, H Yang, B Liu… - Journal of Molecular …, 2022 - Springer
Ketamine is a noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors. Many
experimental studies have shown that ketamine can induce cognitive impairments and …
experimental studies have shown that ketamine can induce cognitive impairments and …
Ketamine as a fast acting antidepressant: current knowledge and open questions
G Salvadore, JB Singh - CNS neuroscience & therapeutics, 2013 - Wiley Online Library
Several recent studies have shown that a single intravenous subanesthetic dose of
ketamine, a NMDA receptor antagonist, exerts rapid antidepressant effects in patients with …
ketamine, a NMDA receptor antagonist, exerts rapid antidepressant effects in patients with …
[HTML][HTML] Effects of ketamine on levels of inflammatory cytokines IL-6, IL-1β, and TNF-α in the hippocampus of mice following acute or chronic administration
Y Li, R Shen, G Wen, R Ding, A Du, J Zhou… - Frontiers in …, 2017 - frontiersin.org
Ketamine is an injectable anesthetic and recreational drug of abuse commonly used
worldwide. Many experimental studies have shown that ketamine can impair cognitive …
worldwide. Many experimental studies have shown that ketamine can impair cognitive …
[HTML][HTML] Antidepressant mechanisms of ketamine: a review of actions with relevance to treatment-resistance and neuroprogression
APM Lullau, EMW Haga, EH Ronold… - Frontiers in …, 2023 - frontiersin.org
Concurrent with recent insights into the neuroprogressive nature of depression, ketamine
shows promise in interfering with several neuroprogressive factors, and has been suggested …
shows promise in interfering with several neuroprogressive factors, and has been suggested …
MEK/ERKs signaling is essential for lithium-induced neurite outgrowth in N2a cells
Z Wang, J Wang, J Li, X Wang, Y Yao, X Zhang… - International Journal of …, 2011 - Elsevier
Lithium, a drug used for the treatment of bipolar disorder, has been shown to affect different
aspects of neuronal development such as neuritogenesis, neurogenesis and survival. The …
aspects of neuronal development such as neuritogenesis, neurogenesis and survival. The …
Creatine, similar to ketamine, counteracts depressive-like behavior induced by corticosterone via PI3K/Akt/mTOR pathway
Ketamine has emerged as a novel strategy to treat refractory depression, producing rapid
remission, but elicits some side effects that limit its use. In an attempt to investigate a safer …
remission, but elicits some side effects that limit its use. In an attempt to investigate a safer …
[HTML][HTML] Transcriptome changes in three brain regions during chronic lithium administration in the rat models of mania and depression
D Szczepankiewicz, P Celichowski… - International Journal of …, 2021 - mdpi.com
Lithium has been the most important mood stabilizer used for the treatment of bipolar
disorder and prophylaxis of manic and depressive episodes. Despite long use in clinical …
disorder and prophylaxis of manic and depressive episodes. Despite long use in clinical …
[HTML][HTML] Chronic lithium treatment alters the excitatory/inhibitory balance of synaptic networks and reduces mGluR5–PKC signalling in mouse cortical neurons
A Khayachi, A Ase, C Liao, A Kamesh… - Journal of Psychiatry and …, 2021 - jpn.ca
Background: Bipolar disorder is characterized by cyclical alternation between mania and
depression, often comorbid with psychosis and suicide. Compared with other medications …
depression, often comorbid with psychosis and suicide. Compared with other medications …