Over the last decade, numerous controlled studies have consistently described rapid, robust,
and relatively sustained antidepressant response rates associated with single-dose …

Although the efficacy of racemate ketamine, a rapid onset and sustained antidepressant, for
patients with treatment-resistant depression was a serendipitous finding, clinical use of …

Ketamine is a noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors. Many
experimental studies have shown that ketamine can induce cognitive impairments and …

Several recent studies have shown that a single intravenous subanesthetic dose of
ketamine, a NMDA receptor antagonist, exerts rapid antidepressant effects in patients with …

Ketamine is an injectable anesthetic and recreational drug of abuse commonly used
worldwide. Many experimental studies have shown that ketamine can impair cognitive …

Concurrent with recent insights into the neuroprogressive nature of depression, ketamine
shows promise in interfering with several neuroprogressive factors, and has been suggested …

Lithium, a drug used for the treatment of bipolar disorder, has been shown to affect different
aspects of neuronal development such as neuritogenesis, neurogenesis and survival. The …

Ketamine has emerged as a novel strategy to treat refractory depression, producing rapid
remission, but elicits some side effects that limit its use. In an attempt to investigate a safer …

Lithium has been the most important mood stabilizer used for the treatment of bipolar
disorder and prophylaxis of manic and depressive episodes. Despite long use in clinical …

Background: Bipolar disorder is characterized by cyclical alternation between mania and
depression, often comorbid with psychosis and suicide. Compared with other medications …