Background A subanesthetic dose of ketamine provides rapid and effective antidepressant
effects, but the molecular mechanism remains elusive. It has been reported that …

Depression is a well-known serious mental illness, and the onset of treatment using
traditional antidepressants is frequently delayed by several weeks. Moreover, numerous …

Recent research into the rapid antidepressant effect of subanesthetic doses of ketamine
have identified a series of relevant protein cascades activated within hours of administration …

Background The NMDA receptor antagonist ketamine was found to act as a fast-acting
antidepressant. The effects of single treatment were reported to persist for days to weeks …

Aim The etiology of bipolar disorder (BD) remains unknown; however, lipid abnormalities in
BD have received increasing attention in recent years. In this study, we examined the …

Ketamine has fast-acting and robust antidepressant effects in animal models and depressed
patients. It has been hypothesized that its underlying mechanism of action is associated with …

Recently, we have shown that ketamine given prior to stress exposure protects against the
development of depressive-like behavior in mice. These data suggest that it may be possible …

Although ketamine shows a rapid and sustained antidepressant effect, the precise
mechanisms underlying its effect are unknown. Recent studies indicate a key role of p11 …

Depression is a common affective disorder characterized by significant and persistent low
mood. Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, is reported to have …

Yueju confers antidepressant effects in a rapid and long-lasting manner, similar to ketamine.
CREB (cAMP-response element binding protein) signaling is implicated in depression …