The co-stimulatory molecule CD28 is essential for activation of helper T cells. Despite this
critical role, it is not known whether CD28 has functions in maintaining T cell responses …

T cell dysfunction is a characteristic feature of chronic viral infection and cancer. Recent
studies in chronic lymphocytic choriomeningitis virus (LCMV) infection have defined a PD-1+ …

Memory T cells, including the well-known CD4+ and CD8+ T cells, are central components
of the acquired immune system and are the basis for successful vaccination. After infection …

The liver is bathed in bacterial products, including lipopolysaccharide transported from the
intestinal portal vasculature, but maintains a state of tolerance that is exploited by persistent …

Virus-specific CD8+ T cells that differentiate in the context of resolved versus persisting
infections exhibit divergent phenotypic and functional characteristics, which suggests that …

We have investigated the contribution of CD4 T cells to the optimal priming of functionally
robust memory CD8 T cell subsets. Intranasal infection of CD4 T cell-deficient (CD4−/−) mice …

Inflammation contributes to the development and perpetuation of several disorders and T
lymphocytes orchestrate the inflammatory immune response. Although the role of T cells in …

▪ Abstract This review summarizes the major features of CD1 genes and proteins, the
patterns of intracellular trafficking of CD1 molecules, and how they sample different …

CD8 T cells comprise a powerful branch of the adaptive immune system, yet were not
formally recognized until long after the discovery of antibody. CD8 T cells contribute to the …

CD8 T cells play an essential role in antitumor immunity and chronic viral infections. Recent
findings have delineated the differentiation pathway of CD8 T cells in accordance with the …