Regulatory CD4+ CD25+ T cells (Treg) are mandatory for maintaining immunologic self-
tolerance. We demonstrate that the cell-cell contact–mediated suppression of conventional …

T cells follow a triphasic distinct pathway of activation, proliferation and differentiation before
becoming functionally and phenotypically “exhausted” in settings of chronic infection …

The appropriate activation of the adaptive immune system relies upon the reprogramming of
naïve T cells into specialized effector T cells that can combat pathogens and tumors. Naïve T …

Naive CD4+ T lymphocytes differentiate into various Th cell subsets following TCR binding
to microbial peptide: MHC class II (p: MHCII) complexes on dendritic cells (DCs). The affinity …

In this study, we compared the proliferation and differentiation of Ag-specific CD4 and CD8 T
cells following Listeria infection. Our results show that CD4 T cells responding to infection …

Chronic viral infections often result in T cell exhaustion. To determine the molecular
signature of exhaustion, we compared the gene-expression profiles of dysfunctional …

Depletion of CD8+ lymphocytes during acute simian immunodeficiency virus (SIV) infection
of rhesus macaques (RMs) results in irreversible prolongation of peak-level viral replication …

Type 17 programmed CD161hiCD8α+ T cells contribute to mucosal immunity to bacteria
and yeast. In early life, microbial colonization induces proliferation of CD161hi cells that is …

Viral infections often induce potent CD8 T cell responses that play a key role in antiviral
immunity. After viral clearance, the vast majority of the expanded CD8 T cells undergo …

Immunological tolerance involves maintaining a state of unresponsiveness to autoantigens
while generating protective immunity against invading pathogens. Recently, a surprising …