We have previously shown that 3-nitro-1H-1, 2, 4-triazole-based arylamides and
arylsulfonamides demonstrate significant activity in vitro against Trypanosoma cruzi, the …

Abstract Human African trypanosomiasis (HAT), Chagas disease and leishmaniasis, which
are caused by the trypanosomatids Trypanosoma brucei, Trypanosoma cruzi and …

Chagas disease is a parasitic infection caused by protozoan Trypanosoma cruzi that affects
approximately 6–7 million people worldwide. Benznidazole is the only drug approved for …

The biological activities of the naphthoquinones lapachol and its cyclization product β-
lapachone, extracted from trees of the genus Tabebuia, have been intensively studied …

Chagas disease, caused by Trypanosoma cruzi, is a parasitosis that predominates in Latin
America. It is estimated that 25 million people are under the risk of infection and, in 2008 …

As a continuation of our research and with the aim of obtaining new agents against Chagas
disease, an extremely neglected disease which threatens 100 million people, eighteen new …

Herein, we present the design, synthesis and trypanocidal evaluation of sixteen new 1, 3, 4-
thiadiazole derivatives from N-aminobenzyl or N-arylhydrazone series. All derivatives were …

Molecules | Free Full-Text | Facile Synthesis of a Series of Non-Symmetric Thioethers Including
a Benzothiazole Moiety and Their Use as Efficient In Vitro anti-Trypanosoma cruzi Agents Next …

Naphtho [2, 3-b] thiophen-4, 9-quinone and five derivatives were prepared using the Friedel-
Crafts reaction and tandem-lithiation of aromatic diethylamides. These quinones were …

Abstract Novel linear 3-nitro-1H-1, 2, 4-triazole-based piperazides were synthesized and
evaluated as antitrypanosomal agents. In addition, some bisarylpiperazine-ethanones which …