In this paper, the design, synthesis and biological evaluation of a set of quinazoline-2, 4, 6-
triamine derivatives (1–9) as trypanocidal, antileishmanial and antiplasmodial agents are …

3-Nitro-1 H-1, 2, 4-triazole-based amides with a linear, rigid core and 3-nitrotriazole-based
fluconazole analogues were synthesized as dual functioning antitrypanosomal agents. Such …

Chagas disease or American trypanosomiasis is a major public health problem in Latin
America. Approximately seven million people are currently infected worldwide. Despite the …

Quinoxalines belong to the N-containing heterocyclic compounds that stand out as having
promising biological activity due to their privileged scaffold. In this work, we report the …

Research in recent years has demonstrated that the Trypanosoma cruzi cysteine protease
cruzain (TCC) is a valid chemotherapeutic target, since inhibitors of this protease affect the …

As a continuation of our project aimed at the search for new and safe chemotherapeutic and
chemoprophylactic agents against American trypanosomiasis (Chagas' disease), several …

New 5-nitroindazole derivatives were developed and their antichagasic properties studied.
Eight compounds (14–18, 20, 26 and 28) displayed remarkable in vitro activities against …

Background Chagas' disease is a condition caused by the protozoan Trypanosoma cruzi
that affects millions of people, mainly in Latin America where it is considered endemic. The …

In this study, we designed and synthesized a series of thiophen-2-iminothiazolidine
derivatives from thiophen-2-thioureic with good anti-Trypanosoma cruzi activity. Several of …

Chagas disease is an infection caused by protozoan Trypanosoma cruzi, which affects
approximately 8–10 million people worldwide. Benznidazole is the only drug approved for …