Oxygen supplementation supports energy production during hypothermic machine perfusion in a model of donation after circulatory death donors

SA Hosgood, ML Nicholson - Transplantation, 2019 - journals.lww.com
Organ preservation has historically relied on the concept that by reducing the temperature to
4 C, cellular metabolism is reduced to approximately 10% of normal. 1 Therefore, it is …

Oxygenated versus standard cold perfusion preservation in kidney transplantation (COMPARE): a randomised, double-blind, paired, phase 3 trial

I Jochmans, A Brat, L Davies, HS Hofker… - The Lancet, 2020 - thelancet.com
Background Deceased donor kidneys are preserved in cold hypoxic conditions. Providing
oxygen during preservation might improve post-transplant outcomes, particularly for kidneys …

Oxygenated end-hypothermic machine perfusion in expanded criteria donor kidney transplant: a randomized clinical trial

P Husen, C Boffa, I Jochmans, C Krikke, L Davies… - JAMA …, 2021 - jamanetwork.com
Importance Continuous hypothermic machine perfusion during organ preservation has a
beneficial effect on graft function and survival in kidney transplant when compared with static …

Effects of oxygen during long-term hypothermic machine perfusion in a porcine model of kidney donation after circulatory death

LH Venema, A Brat, C Moers, NA't Hart, RJ Ploeg… - …, 2019 - journals.lww.com
Background. Hypothermic machine perfusion (HMP) has become standard care in many
center's to preserve kidneys donated after circulatory death (DCD). Despite a significant …

Oxygenated hypothermic machine perfusion of kidneys donated after circulatory death: an international randomised controlled trial

I Jochmans, HS Hofker, L Davies… - 26th BTS Annual …, 2019 - dial.uclouvain.be
METHODS: An international, double-blinded, randomised, paired trial investigated the effect
of oxygenated (HMPO) vs non-oxygenated hypothermic machine perfusion (HMP) on 1y …

Role of oxygenation in hypothermic machine perfusion of kidneys from heart beating donors

A Gallinat, A Paul, P Efferz, B Lüer, S Swoboda… - …, 2012 - journals.lww.com
Dynamic preservation of organ grafts by hypothermic machine perfusion (HMP) has
regained broader interest to provide better outcome after transplantation. One pivotal aspect …

Hypothermic machine perfusion as a national standard preservation method for deceased donor kidneys

A Brat, KM de Vries, EWE van Heurn… - …, 2022 - journals.lww.com
Background. Recently, continuous nonoxygenated hypothermic machine perfusion (HMP)
has been implemented as standard preservation method for deceased donor kidneys in the …

[引用][C] Hypothermic oxygenated machine perfusion—Preliminary experience with end‐ischemic reconditioning of marginal kidney allografts

FA Meister, Z Czigany, J Bednarsch… - Clinical …, 2019 - Wiley Online Library
Dear editor, In the face of critical organ shortage, several machine perfusion (MP) strategies
have been developed aiming at reconditioning poor‐quality extended criteria donor (ECD) …

The effects of oxygenation on ex vivo kidneys undergoing hypothermic machine perfusion

K Patel, TB Smith, DAH Neil, A Thakker… - …, 2019 - journals.lww.com
Background Supplemental oxygenation of the standard hypothermic machine perfusion
(HMP) circuit has the potential to invoke favorable changes in metabolism, optimizing …

Influence of oxygen concentration during hypothermic machine perfusion on porcine kidneys from donation after circulatory death

DP Hoyer, A Gallinat, S Swoboda… - …, 2014 - journals.lww.com
Background Hypothermic machine perfusion (HMP) for preservation led to compelling
success for outcomes of renal transplantation. Application of different concentrations of …